Acyl-CoA Synthetase Long-Chain Family Member 1 (ACSL1) Antibody
364€ (100 µg)
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935106861
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name
Acyl-CoA Synthetase Long-Chain Family Member 1 (ACSL1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx230106
tested applications
ELISA, WB, IHC, IP
Description
ACSL1 Antibody is a Rabbit Polyclonal against ACSL1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Acyl-CoA Synthetase Long-Chain Family Member 1 (ACSL1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/200 - 1/2000, IHC: 1/20 - 1/200, IF/ICC: 1/20 - 1/200, IP: 1/200 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P33121 |
| Gene ID | 2180 |
| OMIM | 152425 |
| Alias | ACS1,LACS,FACL1,FACL2,LACS1,LACS2 |
| Background | Antibody anti-ACSL1 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
ACSL1 is a long-chain acyl-CoA synthetase that activates long-chain fatty acids, converting them into acyl-CoA derivatives for use in β-oxidation, lipid biosynthesis, and signaling pathways. It is highly expressed in energy-demanding tissues such as the heart, liver, and skeletal muscle, where it supports fatty acid metabolism and energy production during fasting and exercise. ACSL1 is critical for directing fatty acids toward oxidation rather than storage, ensuring metabolic flexibility and maintaining energy balance. Its role extends to regulating lipid signaling molecules, such as eicosanoids, which mediate inflammation and other cellular responses. Dysregulation of ACSL1 has been implicated in metabolic disorders, including insulin resistance, diabetes, and non-alcoholic fatty liver disease, where impaired fatty acid activation contributes to disrupted energy homeostasis and lipid accumulation. ACSL1’s enzymatic activity and tissue-specific expression highlight its central role in coordinating lipid metabolism and systemic energy regulation.
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