Acyl-CoA Synthetase Long-Chain Family Member 1 (ACSL1) Antibody

Background

ACSL1 is a long-chain acyl-CoA synthetase that activates long-chain fatty acids, converting them into acyl-CoA derivatives for use in β-oxidation, lipid biosynthesis, and signaling pathways. It is highly expressed in energy-demanding tissues such as the heart, liver, and skeletal muscle, where it supports fatty acid metabolism and energy production during fasting and exercise. ACSL1 is critical for directing fatty acids toward oxidation rather than storage, ensuring metabolic flexibility and maintaining energy balance. Its role extends to regulating lipid signaling molecules, such as eicosanoids, which mediate inflammation and other cellular responses. Dysregulation of ACSL1 has been implicated in metabolic disorders, including insulin resistance, diabetes, and non-alcoholic fatty liver disease, where impaired fatty acid activation contributes to disrupted energy homeostasis and lipid accumulation. ACSL1’s enzymatic activity and tissue-specific expression highlight its central role in coordinating lipid metabolism and systemic energy regulation.