Acyl-CoA Dehydrogenase Family Member 8 (ACAD8) Antibody
357.5€ (100 µg)
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935106861
info@markelab.com
name
Acyl-CoA Dehydrogenase Family Member 8 (ACAD8) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037961
tested applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the ACAD8 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Acyl-CoA Dehydrogenase Family Member 8 (ACAD8) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by Protein A/G column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ACAD-8,ARC42,IBDH |
| Background | Antibody anti-ACAD8 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
ACAD8 is a mitochondrial enzyme involved in the catabolism of isoleucine, a branched-chain amino acid, through its role in the propionyl-CoA pathway. It catalyzes the dehydrogenation of isobutyryl-CoA, an essential step in the breakdown of isoleucine into intermediates that can enter the tricarboxylic acid (TCA) cycle for energy production. ACAD8 is expressed predominantly in tissues with high metabolic activity, including the liver and muscles, where branched-chain amino acid metabolism is critical for energy balance. Mutations in the ACAD8 gene are associated with isobutyryl-CoA dehydrogenase deficiency, a rare metabolic disorder characterized by elevated levels of isobutyryl-carnitine and potential metabolic acidosis. Its role in amino acid metabolism underscores its importance in both energy production and metabolic regulation, particularly during periods of increased energy demand, such as fasting or physical exertion.
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