Activation-Induced Cytidine Deaminase (AICDA) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
Activation-Induced Cytidine Deaminase (AICDA) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx212724
tested applications
ELISA, IHC
Description
AICDA Antibody is a Rabbit Polyclonal against AICDA.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Activation-Induced Cytidine Deaminase (AICDA) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9GZX7 |
| Gene ID | 57379 |
| NCBI Accession | NP_001317272.1 |
| OMIM | 605257 |
| Alias | AID,ARP2,CDA2,HIGM2 |
| Background | Antibody anti-AICDA |
| Status | RUO |
Descripción
Activation-induced cytidine deaminase (AICDA) is an enzyme crucial for the adaptive immune system, specifically in antibody diversification processes. AICDA is primarily expressed in activated B cells within germinal centers and is a key mediator of somatic hypermutation (SHM) and class switch recombination (CSR) in immunoglobulin genes. Through its enzymatic activity, AICDA deaminates cytidine residues in single-stranded DNA, converting them into uracil during transcription, which introduces mutations or facilitates recombination. This targeted mutagenesis is essential for generating high-affinity antibodies and diversifying antibody classes, enabling the immune system to respond effectively to a wide range of antigens. Dysregulation or mutations in AICDA have been linked to immunodeficiency disorders, such as hyper-IgM syndrome, and its aberrant activity is implicated in genomic instability, contributing to oncogenic mutations in lymphomas. AICDA expression is tightly regulated by transcription factors, including E2F and NF-κB, and is further controlled by post-translational modifications such as phosphorylation. Understanding the precise mechanisms of AICDA function and regulation remains critical, as its activity represents both a cornerstone of adaptive immunity and a potential contributor to mutagenesis in malignancies. Researchers continue to explore AICDA as a target for therapeutic intervention in autoimmune diseases and cancer.
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