Activation-Induced Cytidine Deaminase (AICDA) Antibody

Este producto es parte de AICDA - Activation Induced Cytidine Deaminase
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357.5€ (100 µg)

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935106861
info@markelab.com
name
Activation-Induced Cytidine Deaminase (AICDA) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037751
tested applications
ELISA, WB, IHC

Description

Rabbit Polyclonal against the AICDA protein.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Activation-Induced Cytidine Deaminase (AICDA)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by antigen affinity column chromatography.
Size 1
100 µg
Size 2
1 mg
Form
Lyophilized
Tested Applications
ELISA, WB, IHC
Buffer
Prior to lyophilization: 1% BSA and 0.02% NaN3.
Availability
Shipped within 7-15 working days.
Storage
Store at -20 °C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
NCBI Accession
NM_020661
Alias
AID,ARP2,CDA2,HIGM2
Background
Antibody anti-AICDA
Status
RUO
Note
Concentration: Lyophilized form: Not applicable.  After reconstitution: 1 mg/ml. -

Descripción

Activation-induced cytidine deaminase (AICDA) is an enzyme crucial for the adaptive immune system, specifically in antibody diversification processes. AICDA is primarily expressed in activated B cells within germinal centers and is a key mediator of somatic hypermutation (SHM) and class switch recombination (CSR) in immunoglobulin genes. Through its enzymatic activity, AICDA deaminates cytidine residues in single-stranded DNA, converting them into uracil during transcription, which introduces mutations or facilitates recombination. This targeted mutagenesis is essential for generating high-affinity antibodies and diversifying antibody classes, enabling the immune system to respond effectively to a wide range of antigens. Dysregulation or mutations in AICDA have been linked to immunodeficiency disorders, such as hyper-IgM syndrome, and its aberrant activity is implicated in genomic instability, contributing to oncogenic mutations in lymphomas. AICDA expression is tightly regulated by transcription factors, including E2F and NF-κB, and is further controlled by post-translational modifications such as phosphorylation. Understanding the precise mechanisms of AICDA function and regulation remains critical, as its activity represents both a cornerstone of adaptive immunity and a potential contributor to mutagenesis in malignancies. Researchers continue to explore AICDA as a target for therapeutic intervention in autoimmune diseases and cancer.
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