Actinin Alpha 3 (ACTN3) Antibody
273€ (100 µl)
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935106861
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name
Actinin Alpha 3 (ACTN3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx130639
tested applications
WB, IHC
Description
Actinin Alpha 3 Antibody is a Rabbit Polyclonal against Actinin Alpha 3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Actinin Alpha 3 (ACTN3) Immunogen: abx167185 - Recombinant CTN3 (Glu162-Lys416) expressed in E. coli |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ACTN3D |
| Background | Antibody anti-ACTN3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
ACTN3 encodes alpha-actinin-3, a protein primarily expressed in fast-twitch skeletal muscle fibers, where it contributes to muscle strength and power. Unlike its closely related isoform ACTN2, ACTN3 is specialized for rapid and forceful contractions, playing a structural role in maintaining sarcomeric integrity and optimizing muscle performance. A common polymorphism in the ACTN3 gene results in the absence of alpha-actinin-3 in a significant proportion of the population, which has been associated with variations in muscle performance. The "null" variant is linked to reduced muscle power but enhanced endurance, reflecting its evolutionary role in adapting to physical demands. ACTN3 is crucial in regulating the balance between muscle power and endurance, with implications in athletic performance, muscle health, and susceptibility to muscle-related disorders.
Related Products
Human Actinin Alpha 3 (ACTN3) Protein
Human Actinin Alpha 3 Protein is a recombinant Human protein expressed in E. coli.
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