Actin-Like Protein 6B (ACTL6B) Antibody
357.5€ (100 µg)
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Name
Actin-Like Protein 6B (ACTL6B) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx038028
Tested Applications
ELISA, WB
Description
Rabbit Polyclonal against the ACTL6B protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Actin-Like Protein 6B (ACTL6B) Immunogen: Recombinant fragment corresponding to 178-452 AA of human ACTL6B. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 48 kDa |
| Purification | Purified by Protein A/G column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ACTL6,BAF53B,DEE76,EIEE76,IDDSSAD |
| Background | Antibody anti-ACTL6B |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ACTL6B, or BAF53B, is a paralog of ACTL6A and functions primarily in post-mitotic neurons. Like ACTL6A, ACTL6B is part of the SWI/SNF chromatin remodeling complex but is specifically associated with neuronal differentiation and synaptic plasticity. Its structure includes conserved ATP-binding motifs and an actin-like fold, contributing to chromatin interactions. ACTL6B is essential for proper neural circuitry development, as it modulates activity-dependent gene expression. Mutations in ACTL6B have been implicated in neurodevelopmental disorders, including intellectual disabilities and autism spectrum disorders, due to impaired neuronal maturation.
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