Actin-Like Protein 6B (ACTL6B) Antibody

Este producto es parte de ACTL - Actin Like
Actin-Like Protein 6B (ACTL6B) Antibody

Pida mas información

935106861

info@markelab.com

Precio

195€ (20 µl)

Antibody anti-ACTL6B

proveedor

Abbexa

reference

abx005371

Tested Applications

ELISA, WB, IHC, IF/ICC

reactivity

Human, Mouse, Rat

status

RUO

clonality

Polyclonal

Descripción

ACTL6B Antibody is a Rabbit Polyclonal antibody against ACTL6B. The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.


Background

ACTL6B, or BAF53B, is a paralog of ACTL6A and functions primarily in post-mitotic neurons. Like ACTL6A, ACTL6B is part of the SWI/SNF chromatin remodeling complex but is specifically associated with neuronal differentiation and synaptic plasticity. Its structure includes conserved ATP-binding motifs and an actin-like fold, contributing to chromatin interactions. ACTL6B is essential for proper neural circuitry development, as it modulates activity-dependent gene expression. Mutations in ACTL6B have been implicated in neurodevelopmental disorders, including intellectual disabilities and autism spectrum disorders, due to impaired neuronal maturation.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human, Mouse, Rat


immunogen target

Actin-Like Protein 6B (ACTL6B)


host

Rabbit


isotype

IgG


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, WB, IHC, IF/ICC


purification

Purified by affinity chromatography.


recommended dilution

ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.


buffer

PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.


size 1

20 µl


size 2

100 µl


size 3

2 × 100 µl


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

ACTL6B


dry ice

No


availability

Shipped within 5-10 working days.


alias

ACTL6,BAF53B,DEE76,EIEE76,IDDSSAD


NCBI accession

NP_057272.1


note

Concentration: > 0.2 mg/ml -


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