Actin-Like Protein 6B (ACTL6B) Antibody
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935106861
info@markelab.com
Precio
195€ (20 µl)
Antibody anti-ACTL6B
proveedor
Abbexareference
abx005371Tested Applications
ELISA, WB, IHC, IF/ICCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
ACTL6B Antibody is a Rabbit Polyclonal antibody against ACTL6B. The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.
Background
ACTL6B, or BAF53B, is a paralog of ACTL6A and functions primarily in post-mitotic neurons. Like ACTL6A, ACTL6B is part of the SWI/SNF chromatin remodeling complex but is specifically associated with neuronal differentiation and synaptic plasticity. Its structure includes conserved ATP-binding motifs and an actin-like fold, contributing to chromatin interactions. ACTL6B is essential for proper neural circuitry development, as it modulates activity-dependent gene expression. Mutations in ACTL6B have been implicated in neurodevelopmental disorders, including intellectual disabilities and autism spectrum disorders, due to impaired neuronal maturation.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Rat
immunogen target
Actin-Like Protein 6B (ACTL6B)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC, IF/ICC
purification
Purified by affinity chromatography.
recommended dilution
ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
size 1
20 µl
size 2
100 µl
size 3
2 × 100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
ACTL6B
dry ice
No
availability
Shipped within 5-10 working days.
alias
ACTL6,BAF53B,DEE76,EIEE76,IDDSSAD
uniprot id
NCBI accession
NP_057272.1
note
Concentration: > 0.2 mg/ml -
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