Actin Like Protein 6A (ACTL6A) Antibody
292.5€ (80 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Actin Like Protein 6A (ACTL6A) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx029211
Tested Applications
ELISA, WB
Description
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Actin Like Protein 6A (ACTL6A) Immunogen: KLH-conjugated synthetic peptide between 2-30 amino acids from the N-terminal region of human ACTL6A. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 47.5 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O96019 |
| Alias | ACTL6,ARPN-BETA,Arp4,BAF53A |
| Background | Antibody anti-ACTL6A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ACTL6A, also known as BAF53A, is a core component of the SWI/SNF chromatin remodeling complex. It interacts with actin-related proteins and histone modifiers to regulate transcriptional activity and chromatin structure. ACTL6A plays a pivotal role in neural development and stem cell maintenance. Structurally, ACTL6A contains an actin-like ATP-binding domain but does not form filaments like traditional actin. Instead, it stabilizes SWI/SNF complexes, enabling precise control over gene expression during differentiation. Mutations or overexpression of ACTL6A have been linked to cancers, particularly gliomas and squamous cell carcinoma, due to its role in regulating proliferation-related genes.
Productos relacionados
Actin Like Protein 6A (ACTL6A) Antibody
ACTL6A Antibody is a Rabbit Polyclonal antibody against ACTL6A. This gene encodes a family member of actin-related prote…
Ver producto
Actin Like Protein 6A (ACTL6A) Antibody
Rabbit polyclonal antibody against ACTL6A protein. Immunogen region is Internal.…
Ver producto Actin Like Protein 6A (ACTL6A) Antibody
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity…
Ver producto