Actin Like Protein 6A (ACTL6A) Antibody
52€ (10 µg)
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Name
Actin Like Protein 6A (ACTL6A) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx013353
Tested Applications
ELISA, WB, IF/ICC
Description
Rabbit polyclonal antibody against ACTL6A protein. Immunogen region is Internal.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Actin Like Protein 6A (ACTL6A) Immunogen: The antiserum was produced against synthesized peptide derived from internal of human ACL6A. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/3000, IF/ICC: 1/100 - 1/500, ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O96019 |
| Alias | ACTL6,ARPN-BETA,Arp4,BAF53A |
| Background | Antibody anti-ACTL6A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ACTL6A, also known as BAF53A, is a core component of the SWI/SNF chromatin remodeling complex. It interacts with actin-related proteins and histone modifiers to regulate transcriptional activity and chromatin structure. ACTL6A plays a pivotal role in neural development and stem cell maintenance. Structurally, ACTL6A contains an actin-like ATP-binding domain but does not form filaments like traditional actin. Instead, it stabilizes SWI/SNF complexes, enabling precise control over gene expression during differentiation. Mutations or overexpression of ACTL6A have been linked to cancers, particularly gliomas and squamous cell carcinoma, due to its role in regulating proliferation-related genes.
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