Actin Like 7B (Actl7b) Antibody
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Description
The function of this protein remains unknown.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Actin Like 7B (Actl7b) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9QY83 |
| Alias | Tact1 |
| Background | Antibody anti-ACTL7B |
| Status | RUO |
Descripción
ACTL7B is closely related to ACTL7A and is also expressed exclusively in the testis. It is essential for spermatid elongation and nuclear condensation during late spermatogenesis. Structurally, ACTL7B contains conserved actin domains but lacks the polymerization capacity seen in conventional actins. It interacts with chromatin remodeling factors to ensure proper histone-to-protamine transition in spermatids. Loss or mutations in ACTL7B can impair spermatid differentiation, resulting in male infertility. Its specialized function highlights the diversity of actin-like proteins in reproductive biology.
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anti- ACTL7B antibody
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Actin Like 7B (ACTL7B) Antibody
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known.
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