Acidic Nuclear Phosphoprotein 32 Family Member E (ANP32E) Antibody

Background

ANP32E is a critical regulator of histone dynamics, particularly in the incorporation and removal of histone variant H2A.Z. Through its role in modulating H2A.Z deposition, ANP32E influences chromatin accessibility, gene transcription, and DNA damage repair. It functions as a histone chaperone, ensuring proper regulation of chromatin structure to maintain genomic stability and support essential cellular processes. ANP32E is essential for cellular differentiation, development, and responses to DNA damage. Dysregulation of ANP32E is associated with cancer, where alterations in histone variant dynamics contribute to abnormal transcriptional programs that drive tumorigenesis. Its role in maintaining chromatin integrity highlights its importance in epigenetic regulation and cellular stress responses.