Acetyl-Coenzyme A Synthetase, Cytoplasmic (ACSS2) Antibody
357.5€ (100 µg)
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935106861
info@markelab.com
name
Acetyl-Coenzyme A Synthetase, Cytoplasmic (ACSS2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037998
tested applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the ACSS2 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Acetyl-Coenzyme A Synthetase, Cytoplasmic (ACSS2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by Protein A/G column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ACAS2,ACECS,ACS,ACSA |
| Background | Antibody anti-ACSS2 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
ACSS2 is a cytosolic and nuclear enzyme that catalyzes the activation of acetate into acetyl-CoA, playing a central role in lipid synthesis, histone acetylation, and energy metabolism. It is highly expressed in the liver, adipose tissue, and brain, where it contributes to diverse metabolic and regulatory processes. In the nucleus, ACSS2 provides acetyl-CoA for histone acetylation, influencing gene expression and cellular responses to environmental changes. In the cytoplasm, it supports lipogenesis and cholesterol synthesis by activating acetate for incorporation into fatty acids and sterols. ACSS2 also plays a role in cancer metabolism by providing acetyl-CoA to fuel biosynthetic pathways in rapidly proliferating cells. Dysregulation of ACSS2 has been implicated in cancer progression, metabolic syndromes, and neurodegenerative diseases, highlighting its critical function in integrating metabolic and epigenetic regulation.
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