Acetyl-Coenzyme A Synthetase, Cytoplasmic (ACSS2) Antibody
195€ (20 µl)
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935106861
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name
Acetyl-Coenzyme A Synthetase, Cytoplasmic (ACSS2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx004962
tested applications
ELISA, WB, IF/ICC
Description
ACSS2 Antibody is a Rabbit Polyclonal antibody against ACSS2. This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Acetyl-Coenzyme A Synthetase, Cytoplasmic (ACSS2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NR19 |
| Gene ID | 55902 |
| NCBI Accession | NP_061147.1 |
| Alias | ACAS2,ACECS,ACS,ACSA |
| Background | Antibody anti-ACSS2 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
ACSS2 is a cytosolic and nuclear enzyme that catalyzes the activation of acetate into acetyl-CoA, playing a central role in lipid synthesis, histone acetylation, and energy metabolism. It is highly expressed in the liver, adipose tissue, and brain, where it contributes to diverse metabolic and regulatory processes. In the nucleus, ACSS2 provides acetyl-CoA for histone acetylation, influencing gene expression and cellular responses to environmental changes. In the cytoplasm, it supports lipogenesis and cholesterol synthesis by activating acetate for incorporation into fatty acids and sterols. ACSS2 also plays a role in cancer metabolism by providing acetyl-CoA to fuel biosynthetic pathways in rapidly proliferating cells. Dysregulation of ACSS2 has been implicated in cancer progression, metabolic syndromes, and neurodegenerative diseases, highlighting its critical function in integrating metabolic and epigenetic regulation.
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