Abhydrolase Domain Containing 1 (ABHD1) Antibody

Background

ABHD1 is a member of the alpha/beta hydrolase superfamily, functioning as a serine hydrolase with roles in lipid metabolism and signaling. It is expressed in a variety of tissues, including the liver, brain, and immune cells, where it regulates lipid hydrolysis, particularly lysophospholipids, which are critical for maintaining cellular lipid balance. ABHD1 contributes to processes such as lipid signaling, membrane remodeling, and energy metabolism. Emerging studies suggest its involvement in modulating inflammatory responses, likely through its regulation of bioactive lipids that serve as signaling molecules. While the physiological substrates of ABHD1 are not fully characterized, its enzymatic activity has been implicated in maintaining metabolic homeostasis, with dysregulation linked to inflammation and metabolic disorders. The functional versatility of ABHD1 and its potential role in lipid-related diseases make it a promising target for therapeutic exploration.