A-Kinase Anchor Protein 8 Like (AKAP8L) Antibody
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935106861
info@markelab.com
Precio
250€ (50 µl)
Antibody anti-AKAP8L
proveedor
Abbexareference
abx213051Tested Applications
ELISA, WB, IHCreactivity
Human, Mousestatus
RUOclonality
PolyclonalDescripción
AKAP8L Antibody is a Rabbit Polyclonal against AKAP8L.
Background
A Kinase Anchor Protein 8-Like (AKAP8L) is a member of the AKAP family of scaffolding proteins that anchor protein kinase A (PKA) and other signaling molecules to specific subcellular locations, thereby compartmentalizing signaling pathways. AKAP8L is predominantly localized in the nucleus, where it plays a critical role in RNA processing, chromatin remodeling, and transcriptional regulation. It is involved in coordinating events such as mRNA splicing and nuclear export, and it may also contribute to mitotic progression through its interactions with chromatin-associated proteins. AKAP8L facilitates the integration of signaling cascades with gene expression, highlighting its role in cellular adaptation to external and internal cues. Dysregulation of AKAP8L has been implicated in cancer and other diseases, where disrupted nuclear signaling and chromatin dynamics affect cell proliferation and survival. Emerging research suggests AKAP8L’s involvement in stress responses, particularly in modulating nuclear processes under conditions of DNA damage or oxidative stress, making it a potential target for therapeutic intervention.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse
immunogen target
A-Kinase Anchor Protein 8 Like (AKAP8L)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC
purification
Antigen Affinity Chromatography.
buffer
PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol.
size 1
50 µl
size 2
100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
AKAP8L
dry ice
No
availability
Shipped within 5-10 working days.
alias
NAKAP, NAKAP95
uniprot id
note
This product is for research use only.
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