A-Kinase Anchor Protein 5 (AKAP5) Antibody
357.5€ (100 µg)
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Name
A-Kinase Anchor Protein 5 (AKAP5) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx037329
Tested Applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the AKAP5 protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: A-Kinase Anchor Protein 5 (AKAP5) Immunogen: Recombinant fragment corresponding to 171-417 AA of human AKAP5. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 47 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | BC131516 |
| Alias | AKAP5, AKAP79 |
| Background | Antibody anti-AKAP5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AKAP5, also known as AKAP79/150, is a cytosolic scaffold protein that anchors PKA, PKC, and calcineurin to the plasma membrane in neurons, cardiac tissue, and epithelial cells. AKAP5 is highly enriched in synapses, where it organizes signaling complexes that regulate synaptic plasticity, neurotransmitter release, and calcium signaling. It interacts with AMPA and NMDA receptors, ensuring the spatial regulation of PKA and PKC signaling necessary for synaptic strength and long-term potentiation (LTP), processes critical for learning and memory. AKAP5 also plays a role in cardiac function, where it regulates ion channels, such as L-type calcium channels, influencing cardiac excitation-contraction coupling. Dysregulation of AKAP5 disrupts neuronal signaling, leading to cognitive deficits, psychiatric disorders, and neurodegenerative diseases. Additionally, AKAP5 regulates receptor internalization and trafficking, highlighting its role in cellular signaling and membrane dynamics.
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