A-Kinase Anchor Protein 12 (AKAP12) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
A-Kinase Anchor Protein 12 (AKAP12) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx230252
tested applications
ELISA, WB, IHC
Description
AKAP12 Antibody is a Rabbit Polyclonal against AKAP12.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | A-Kinase Anchor Protein 12 (AKAP12) |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Recommended Dilution | WB: 1/200 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q02952 |
| Gene ID | 9590 |
| Alias | AKAP250,SSeCKS |
| Background | Antibody anti-AKAP12 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
AKAP12, also known as gravin, is a multifunctional scaffold protein that binds PKA, PKC, and other kinases, organizing signaling pathways at the plasma membrane and cytoskeleton. AKAP12 plays a critical role in cell adhesion, migration, and proliferation by coordinating cAMP and PKC signaling in focal adhesions. It regulates cytoskeletal remodeling and cell polarity by interacting with actin-binding proteins, influencing processes like wound healing and cancer metastasis. AKAP12 acts as a tumor suppressor in various cancers, where its loss leads to dysregulated signaling pathways, including ERK/MAPK and cell cycle progression. AKAP12 is also involved in vascular homeostasis, where it regulates endothelial barrier function and angiogenesis. Studies highlight AKAP12’s role in stress responses, particularly in regulating PKA signaling during inflammation and oxidative stress. Additionally, AKAP12 expression is regulated by epigenetic mechanisms, such as promoter methylation, which contributes to its silencing in cancer cells.
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