A Disintegrin And Metalloprotease 15 (ADAM15) Antibody
357.5€ (100 µg)
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Name
A Disintegrin And Metalloprotease 15 (ADAM15) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx038403
Tested Applications
ELISA, WB
Description
Rabbit Polyclonal against the ADAM15 protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: A Disintegrin And Metalloprotease 15 (ADAM15) Immunogen: A peptide corresponding to the N-terminal region of human ADAM15 protein. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 55 kDa, 70-110 kDa |
| Purification | Purified by Protein A/G column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_003815 |
| Alias | MDC15,MDC-15,Metargidin,ADAM-15 |
| Background | Antibody anti-ADAM15 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ADAM15, also known as ADAM metallopeptidase domain 15, is a member of the ADAM (a disintegrin and metalloproteinase) family . These proteins are involved in various biological processes, including cell adhesion, migration, proteolysis, and signaling. ADAM15 is a transmembrane protein, meaning it spans the cell membrane, with both extracellular and intracellular domains.ADAM15 consists of several distinct domains, including a metalloproteinase domain responsible for its proteolytic activity, a disintegrin domain involved in cell-cell and cell-matrix interactions, a cysteine-rich domain, an EGF-like domain, a transmembrane domain, and a cytoplasmic tail.ADAM15 is implicated in various physiological and pathological processes, including cell adhesion, migration, proliferation, and signaling. It can cleave cell surface proteins, releasing soluble forms of these proteins into the extracellular environment. Is also involved in cell-cell and cell-matrix interactions. It interacts with various proteins on the cell surface and in the extracellular matrix, including integrins, growth factors, cytokines, and cell adhesion molecules.ADAM15 has been linked to cancer progression and metastasis. Its expression is often elevated in various cancers, including breast, lung, colon, prostate, and pancreatic cancers. ADAM15 can promote tumor cell invasion and metastasis by facilitating cell migration and invasion through the extracellular matrix.
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