5-Hydroxytryptamine Receptor 3D (HTR3D) Antibody

Este producto es parte de HTR - 5-Hydroxytryptamine receptors
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221€ (50 µg)

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935106861
info@markelab.com
name
5-Hydroxytryptamine Receptor 3D (HTR3D) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx324193
tested applications
ELISA, WB, IF/ICC

Description

HTR3D Antibody is a Rabbit Polyclonal against HTR3D.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
5-Hydroxytryptamine Receptor 3D (HTR3D)
Host
Rabbit
Reactivity
Human
Recommended Dilution
ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by affinity chromatography.
Size 1
50 µg
Size 2
100 µg
Form
Liquid
Tested Applications
ELISA, WB, IF/ICC
Buffer
PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q70Z44
Gene ID
200909
Alias
HTR3D,5HT3D,5-HT3D receptor
Background
Antibody anti-HTR3D
Status
RUO

Descripción

HTR3D is a lesser-known subunit of the 5-HT3 receptor family, which functions as a ligand-gated ion channel. HTR3D assembles with the HTR3A subunit to form functional receptor complexes but does not form channels independently. Its co-expression with HTR3A influences the conductance, ion permeability, and pharmacological characteristics of the receptor. HTR3D is primarily expressed in the gastrointestinal tract, particularly in the enteric nervous system, where it modulates serotonin-mediated functions such as nausea, vomiting, and bowel motility. Its role in pain processing and visceral hypersensitivity has made it an emerging target for irritable bowel syndrome (IBS) and other functional gastrointestinal disorders. Genetic polymorphisms in the HTR3D gene have been associated with altered responses to 5-HT3 receptor antagonists, indicating its importance in personalizing therapies for chemotherapy-induced nausea and vomiting (CINV) and other serotonin-related disorders. Further research into HTR3D's function and interactions may reveal its broader contributions to neurotransmission and pharmacological modulation.

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