5-Hydroxytryptamine Receptor 1F / 5-HT1F (HTR1F) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
5-Hydroxytryptamine Receptor 1F / 5-HT1F (HTR1F) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx013885
tested applications
ELISA, WB
Description
Rabbit polyclonal antibody against 5-HT-1F protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | 5-Hydroxytryptamine Receptor 1F / 5-HT1F (HTR1F) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/40000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P30939 |
| Alias | HTR1F,5HT6, MR77, 5-HT1F, HTR1EL, 5-HT-1F,5-HT1F receptor |
| Background | Antibody anti-HTR1F |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
HTR1F is a G protein-coupled receptor (GPCR) and a member of the serotonin receptor family, involved in mediating serotonin's effects on neuronal signaling, vasoconstriction, and pain modulation. HTR1F is predominantly expressed in the trigeminal nerve pathways and meningeal blood vessels, where it regulates vascular tone and inflammatory responses. It is most well-known for its role in the treatment of migraine headaches, where activation of HTR1F receptors leads to the inhibition of pain transmission without causing vasoconstriction, unlike other serotonin receptors. Selective agonists, such as lasmiditan, specifically target HTR1F to relieve migraine symptoms by reducing the excitability of trigeminal neurons and limiting the release of pro-inflammatory neuropeptides. In addition to its role in migraine management, HTR1F may contribute to modulating mood, anxiety, and cognitive functions. Its unique ability to alleviate migraine pain without affecting vascular constriction makes it a safer alternative for individuals with cardiovascular risks. Ongoing research into HTR1F's mechanisms of action highlights its potential as a therapeutic target not only for migraine treatment but also for neuroinflammatory conditions, mood stabilization, and pain-related disorders.
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