5-Hydroxytryptamine Receptor 1A / 5-HT1A (HTR1A) Antibody
260€ (50 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
5-Hydroxytryptamine Receptor 1A / 5-HT1A (HTR1A) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx214986
Tested Applications
ELISA, WB, IHC
Description
HTR1A Antibody is a Rabbit Polyclonal against HTR1A.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: 5-Hydroxytryptamine Receptor 1A / 5-HT1A (HTR1A) Immunogen: Synthetic peptide of human HTR1A. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/2000 - 1/10000, WB: 1/1000 - 1/5000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08908 |
| Gene ID | 3350 |
| Alias | HTR1A,G-21,5HT1a,PFMCD,5-HT1A,5-HT-1A,ADRBRL1,ADRB2RL1,5-HT1A receptor |
| Background | Antibody anti-HTR1A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
HTR1A, a subtype of the serotonin receptor family, is a G protein-coupled receptor (GPCR) responsible for mediating the effects of serotonin (5-HT), a neurotransmitter essential for regulating mood, anxiety, and behavior. Predominantly expressed in the central nervous system, particularly in regions such as the hippocampus, cerebral cortex, and raphe nuclei, HTR1A plays a key role in modulating neuronal excitability and synaptic transmission. Activation of HTR1A leads to the inhibition of adenylyl cyclase, reducing cyclic AMP (cAMP) levels and promoting cellular hyperpolarization, which reduces neuronal firing. Dysregulation of HTR1A has been associated with mood disorders such as depression, anxiety, and schizophrenia, making it a key target for anxiolytic and antidepressant drugs such as SSRIs (selective serotonin reuptake inhibitors) and buspirone. Additionally, HTR1A is involved in neurogenesis, stress response regulation, and cognitive function. Emerging evidence suggests that HTR1A also has neuroprotective properties by reducing oxidative stress, modulating mitochondrial function, and preventing apoptosis in neurons. HTR1A's diverse roles in mood regulation, stress resilience, and cognitive function make it a significant therapeutic target for treating mood disorders, neurodegenerative diseases, and cognitive dysfunction. Ongoing research is investigating its potential for enhancing neuroplasticity and stress resilience in mental health disorders.
Productos relacionados
5-Hydroxytryptamine Receptor 1A / 5-HT1A (HTR1A) Antibody
5-HT-1A Antibody is a Rabbit Polyclonal antibody against 5-HT-1A.…
Ver producto
5-Hydroxytryptamine Receptor 1A / 5-HT1A (HTR1A) Antibody
5-Hydroxytryptamine Receptor 1A / 5-HT1A (HTR1A) Antibody is a Rabbit Polyclonal antibody for the detection of HTR1A.…
Ver producto
Human 5-Hydroxytryptamine Receptor 1A / 5-HT1A (HTR1A) ELISA Kit
Human 5-Hydroxytryptamine Receptor 1A / 5-HT1A (HTR1A) ELISA Kit is an ELISA Kit for the in vitro quantitative measureme…
Ver producto