5-Hydroxytryptamine Receptor 1A / 5-HT1A (HTR1A) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
5-Hydroxytryptamine Receptor 1A / 5-HT1A (HTR1A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx119085
tested applications
WB
Description
5-HT-1A Antibody is a Rabbit Polyclonal antibody against 5-HT-1A.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | 5-Hydroxytryptamine Receptor 1A / 5-HT1A (HTR1A) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08908 |
| Alias | HTR1A,G-21,5HT1a,PFMCD,5-HT1A,5-HT-1A,ADRBRL1,ADRB2RL1,5-HT1A receptor |
| Background | Antibody anti-HTR1A |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
HTR1A, a subtype of the serotonin receptor family, is a G protein-coupled receptor (GPCR) responsible for mediating the effects of serotonin (5-HT), a neurotransmitter essential for regulating mood, anxiety, and behavior. Predominantly expressed in the central nervous system, particularly in regions such as the hippocampus, cerebral cortex, and raphe nuclei, HTR1A plays a key role in modulating neuronal excitability and synaptic transmission. Activation of HTR1A leads to the inhibition of adenylyl cyclase, reducing cyclic AMP (cAMP) levels and promoting cellular hyperpolarization, which reduces neuronal firing. Dysregulation of HTR1A has been associated with mood disorders such as depression, anxiety, and schizophrenia, making it a key target for anxiolytic and antidepressant drugs such as SSRIs (selective serotonin reuptake inhibitors) and buspirone. Additionally, HTR1A is involved in neurogenesis, stress response regulation, and cognitive function. Emerging evidence suggests that HTR1A also has neuroprotective properties by reducing oxidative stress, modulating mitochondrial function, and preventing apoptosis in neurons. HTR1A's diverse roles in mood regulation, stress resilience, and cognitive function make it a significant therapeutic target for treating mood disorders, neurodegenerative diseases, and cognitive dysfunction. Ongoing research is investigating its potential for enhancing neuroplasticity and stress resilience in mental health disorders.
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This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers.
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