14-3-3 Protein Zeta/Delta Phospho-Ser58 (YWHAZ pS58) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
14-3-3 Protein Zeta/Delta Phospho-Ser58 (YWHAZ pS58) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx012400
tested applications
ELISA, WB, IHC, IF/ICC
Description
Rabbit polyclonal antibody against 14-3-3 Protein Zeta/Deltaprotein phosphorylated at Serine 58. Immunogen region is Internal. Specificity is as follows for the reactive species: H:S58, M:S58, R:S58.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | 14-3-3 Protein Zeta/Delta Phospho-Ser58 (YWHAZ pS58) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Data | Modification: Phosphorylation // Target Modification: Ser58 |
| Recommended Dilution | WB: 1/500 - 3000, IHC: 1/50 - 100, IF/ICC: 1/100 - 1/500, ELISA: 1/40000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P63104 |
| Alias | YWHAZ, 14-3-3-zeta, HEL-S-3, HEL4, KCIP-1, YWHAD, HEL-S-93, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta, POPCHAS |
| Background | Antibody anti-YWHAZ |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
YWHAZ, a member of the 14-3-3 protein family, is a highly conserved adaptor protein that regulates signal transduction by binding to phosphorylated serine/threonine residues on target proteins. It functions as a molecular scaffold, facilitating protein-protein interactions involved in diverse cellular processes, including cell cycle progression, apoptosis, and signal transduction. YWHAZ plays a role in regulating pathways such as PI3K/Akt, MAPK, and TGF-β, influencing cell survival, proliferation, and migration. It is abundantly expressed in the brain and immune tissues, where it is critical for neuronal development, synaptic plasticity, and stress responses. Dysregulation of YWHAZ is implicated in neurological disorders, cancer progression, and metabolic diseases due to its role in stabilizing oncogenic and signaling proteins. Knockout studies reveal defects in brain development, increased apoptosis, and impaired cell signaling, underscoring its essential role as a key regulator of cellular homeostasis and signaling pathways.
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This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.
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