14-3-3 Protein Theta (YWHAQ) ELISA Kit
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Description
14-3-3 Protein Theta (YWHAQ) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human, Mouse, Rat 14-3-3 protein theta concentrations in serum, plasma, tissue homogenates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | 14-3-3 Protein Theta (YWHAQ) |
| Reactivity | Human, Mouse, Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.06 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | YWHAQ, 14-3-3, 1C5, HS1, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta |
| Background | Elisa kits for YWHAQ |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
YWHAQ, also known as 14-3-3 theta, functions as a scaffold protein that regulates signal transduction, apoptosis, and cell cycle progression by binding phosphorylated proteins. It interacts with signaling molecules involved in pathways such as MAPK, PI3K/Akt, and TGF-β, facilitating processes like cellular growth, survival, and differentiation. YWHAQ is abundantly expressed in neuronal tissues and skeletal muscle, where it plays a role in synaptic function, axonal transport, and cellular energy metabolism. It regulates neuroprotective pathways by stabilizing proteins involved in neuronal survival and oxidative stress responses. Dysregulation of YWHAQ is linked to neurodegenerative diseases such as Parkinson’s and Huntington’s, where its dysfunction leads to impaired signaling and protein aggregation. In cancer, overexpression of YWHAQ promotes cell proliferation and migration through its effects on oncogenic signaling pathways. Knockout studies demonstrate defects in cell survival, impaired neuronal development, and altered metabolic responses, highlighting its role in neuroprotection, cellular stability, and disease regulation.
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YWHAQ antibody
14-3-3 theta(also known as YWHAQ, or 14-3-3 tau) is a member of 14-3-3 proteins which were the first phosphoserine/phosphothreonine-binding proteins to be discovered. 14-3-3 family members interact with a wide spectrum of proteins and possess diverse functions. Mammals express seven distinct 14-3-3 isoforms(gamma, epsilon, beta, zeta, sigma, theta, tau) that form multiple homo-and hetero-dimmers. 14-3-3 proteins display the highest expression levels in the brain, and have been implicated in several neurodegenerative diseases, including Alzheimer's disease and amyotrophic lateral sclerosis. This antibody was raised against full-length 14-3-3 theta.
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14-3-3 theta(also known as YWHAQ, or 14-3-3 tau) is a member of 14-3-3 proteins which were the first phosphoserine/phosphothreonine-binding proteins to be discovered. 14-3-3 family members interact with a wide spectrum of proteins and possess diverse functions. Mammals express seven distinct 14-3-3 isoforms(gamma, epsilon, beta, zeta, sigma, theta, tau) that form multiple homo-and hetero-dimmers. 14-3-3 proteins display the highest expression levels in the brain, and have been implicated in several neurodegenerative diseases, including Alzheimer's disease and amyotrophic lateral sclerosis. This antibody was raised against full-length 14-3-3 theta.
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