14-3-3 Protein Beta/Alpha (YWHAB) Antibody Pair
988€ (5 × 96 tests)
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Name
14-3-3 Protein Beta/Alpha (YWHAB) Antibody Pair
Category
Antibody Pairs
Provider
Abbexa
Reference
abx117305
Tested Applications
ELISA
Description
YWHAB Antibody Pair for use in Sandwich ELISA assay development. This antibody pair contains the capture antibody and the detection antibody necessary to prepare five 96-well ELISA kit plates.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Antibody Pairs |
| Immunogen Target | 14-3-3 Protein Beta/Alpha (YWHAB) |
| Host | Capture Host: Rabbit Detection Host: Rabbit |
| Reactivity | Human, Rat, Mouse, Guinea pig, Cow, Horse, Pig, Dog, Chicken, Goat, Sheep |
| Assay Type | Sandwich |
| Clonality | Capture Clonality: Polyclonal Detection Clonality: Polyclonal |
| Conjugation | Biotin |
| Isotype | Capture Isotype: IgG Detection Isotype: IgG |
| Size 1 | 5 × 96 tests |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | YWHAB, GW128, HEL-S-1, HS1, KCIP-1, YWHAA, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta,14-3-3 alpha,14-3-3 beta |
| Background | Antibody pair for YWHAB |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
YWHAB, part of the 14-3-3 protein family, functions as a scaffold protein that binds to phosphorylated serine/threonine-containing motifs, regulating protein localization, stability, and signaling pathways. It is involved in processes such as cell cycle control, DNA damage response, apoptosis, and stress adaptation by interacting with key signaling proteins, including Raf kinases, BAD, and CDC25. YWHAB regulates pathways like MAPK and PI3K/Akt, influencing cellular growth, survival, and metabolism. It is ubiquitously expressed, with high levels in the brain, where it contributes to synaptic plasticity, neuroprotection, and neuronal development. Dysregulation of YWHAB has been associated with neurodegenerative diseases, including Alzheimer’s and Parkinson’s, as well as cancer, where altered protein interactions promote tumor survival and metastasis. Knockout studies show defects in cellular proliferation, increased apoptosis, and impaired stress responses, highlighting its role in maintaining cellular stability and signaling balance.
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