1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (AGPAT2) Antibody
169€ (20 µl)
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Name
1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (AGPAT2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx321790
Tested Applications
ELISA, WB, IHC
Description
AGPAT2 Antibody is a Rabbit Polyclonal against AGPAT2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: 1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (AGPAT2) Immunogen: Recombinant human 1-acyl-sn-glycerol-3-phosphate acyltransferase beta protein (199-278AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000 - 1/5000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15120 |
| Gene ID | 10555 |
| NCBI Accession | NP_001012745.1, NM_001012727.1, NP_006403.2, NM_006412.3 |
| OMIM | 603100 |
| Alias | 1-AGPAT2,BSCL,BSCL1 |
| Background | Antibody anti-AGPAT2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AGPAT2 is a central enzyme in triglyceride and phospholipid biosynthesis, catalyzing the acylation of lysophosphatidic acid (LPA) to produce phosphatidic acid (PA). AGPAT2 is predominantly expressed in adipose tissue, where it regulates the production of glycerophospholipids and triglycerides. It plays a vital role in adipogenesis and lipid storage, contributing to the formation of functional lipid droplets. Mutations in the AGPAT2 gene are linked to congenital generalized lipodystrophy type 1 (CGL1), a disorder characterized by the near absence of adipose tissue, insulin resistance, and hypertriglyceridemia. The loss of AGPAT2 activity disrupts lipid metabolism, resulting in severe metabolic dysfunction.
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