1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (AGPAT2) Antibody

Este producto es parte de AGPAT - 1-acyl-sn-glycerol-3-phosphate acyltransferase
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312€ (60 µl)

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935106861
info@markelab.com
name
1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (AGPAT2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx004998
tested applications
WB, IF/ICC

Description

AGPAT2 Antibody is a Rabbit Polyclonal antibody against AGPAT2. This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (AGPAT2)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by affinity chromatography.
Size 1
60 µl
Size 2
120 µl
Size 3
200 µl
Form
Liquid
Tested Applications
WB, IF/ICC
Buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O15120
Gene ID
10555
NCBI Accession
NP_006403.2
Alias
1-AGPAT2,BSCL,BSCL1
Background
Antibody anti-AGPAT2
Status
RUO
Note
Concentration: 1 mg/ml -

Descripción

AGPAT2 is a central enzyme in triglyceride and phospholipid biosynthesis, catalyzing the acylation of lysophosphatidic acid (LPA) to produce phosphatidic acid (PA). AGPAT2 is predominantly expressed in adipose tissue, where it regulates the production of glycerophospholipids and triglycerides. It plays a vital role in adipogenesis and lipid storage, contributing to the formation of functional lipid droplets. Mutations in the AGPAT2 gene are linked to congenital generalized lipodystrophy type 1 (CGL1), a disorder characterized by the near absence of adipose tissue, insulin resistance, and hypertriglyceridemia. The loss of AGPAT2 activity disrupts lipid metabolism, resulting in severe metabolic dysfunction.

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