1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (AGPAT2) Antibody
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Description
AGPAT2 Antibody is a Rabbit Polyclonal antibody against AGPAT2. This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | 1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (AGPAT2) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15120 |
| Gene ID | 10555 |
| NCBI Accession | NP_006403.2 |
| Alias | 1-AGPAT2,BSCL,BSCL1 |
| Background | Antibody anti-AGPAT2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
AGPAT2 is a central enzyme in triglyceride and phospholipid biosynthesis, catalyzing the acylation of lysophosphatidic acid (LPA) to produce phosphatidic acid (PA). AGPAT2 is predominantly expressed in adipose tissue, where it regulates the production of glycerophospholipids and triglycerides. It plays a vital role in adipogenesis and lipid storage, contributing to the formation of functional lipid droplets. Mutations in the AGPAT2 gene are linked to congenital generalized lipodystrophy type 1 (CGL1), a disorder characterized by the near absence of adipose tissue, insulin resistance, and hypertriglyceridemia. The loss of AGPAT2 activity disrupts lipid metabolism, resulting in severe metabolic dysfunction.
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1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (AGPAT2) Antibody
AGPAT2 Antibody is a Rabbit Polyclonal antibody against AGPAT2. This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (AGPAT2) Antibody
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AGPAT2 Antibody is a Rabbit Polyclonal against AGPAT2.
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