1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (AGPAT2) Antibody

Background

AGPAT2 is a central enzyme in triglyceride and phospholipid biosynthesis, catalyzing the acylation of lysophosphatidic acid (LPA) to produce phosphatidic acid (PA). AGPAT2 is predominantly expressed in adipose tissue, where it regulates the production of glycerophospholipids and triglycerides. It plays a vital role in adipogenesis and lipid storage, contributing to the formation of functional lipid droplets. Mutations in the AGPAT2 gene are linked to congenital generalized lipodystrophy type 1 (CGL1), a disorder characterized by the near absence of adipose tissue, insulin resistance, and hypertriglyceridemia. The loss of AGPAT2 activity disrupts lipid metabolism, resulting in severe metabolic dysfunction.