Human Myotubularin-related protein 13 (SBF2) ELISA Kit

Product specifications

ELISA Kits

Myotubularin-related protein 13 (SBF2)

Human

Colorimetric

Quantitative

0.156 ng/ml - 10 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-15 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

Q86WG5

CMT4B2,MTMR13,DENND7B,SET-binding factor 2,Inactive phosphatidylinositol 3-phosphatase 13,Myotubularin-related protein 13

Elisa kits for SBF2

RUO

Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

SBF2, also referred to as SET-binding factor 2, is a pseudophosphatase similar to SBF1 but is more directly implicated in vesicular trafficking and peripheral nervous system function. Like SBF1, SBF2 belongs to the myotubularin-related protein family and lacks phosphatase activity, serving instead as a regulator of phosphoinositide signaling pathways. It is critical for endosomal trafficking, particularly in sorting and recycling processes, by interacting with Rab GTPases and other components of the endocytic machinery. Mutations in SBF2 are causative for Charcot-Marie-Tooth disease type 4B2 (CMT4B2), a severe demyelinating neuropathy, underscoring its importance in maintaining axonal and Schwann cell function. SBF2 interacts with SBF1, forming a complex that regulates membrane dynamics and lipid signaling, with evidence suggesting that the partnership enhances the stability and functionality of endosomal systems. SBF2 expression is enriched in the nervous system, particularly in peripheral nerves and the brain, aligning with its role in neural homeostasis. Structural analysis reveals that SBF2 contains conserved coiled-coil and PH domains that mediate interactions with lipids and proteins, further supporting its scaffolding function. SBF2 also appears to influence cytoskeletal organization and intracellular signaling cascades, including the PI3K-AKT pathway, linking it to cell growth and survival processes. Recent studies highlight a potential role for SBF2 in cancer progression, suggesting that it may regulate tumor cell migration and invasion through its effects on vesicular trafficking and signaling.

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SBF2 Antibody (HRP) is a Rabbit Polyclonal against SBF2 conjugated to HRP.

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Myotubularin-Related Protein 13 (SBF2) Antibody (FITC)

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