Family main features
Nuclear Receptor Subfamily 6 Group A Member 1 (NR6A1), also known as Germ Cell Nuclear Factor (GCNF), is a transcription factor involved in regulating gene expression during embryonic development and germ cell differentiation. NR6A1 is part of the nuclear receptor superfamily, which consists of receptors that regulate diverse physiological processes by modulating the expression of specific target genes. It plays a crucial role in the development of the central nervous system, somatic tissues, and the formation of primordial germ cells. NR6A1 is highly conserved across vertebrates, indicating its essential functions in development and cellular differentiation.
The NR6A1 protein structure includes:
NR6A1 belongs to the nuclear receptor subfamily 6 group A, characterized by specific roles in reproductive and developmental processes. There are no major subtypes of NR6A1; instead, it is a unique member of this subfamily with distinct functional roles.
NR6A1 is a critical nuclear receptor involved in the regulation of gene expression during key developmental processes, including germ cell differentiation and embryogenesis. Its protein structure, with distinct NTD, DBD, hinge region, and LBD, facilitates its role as a transcriptional regulator. NR6A1 functions primarily as a repressor of gene expression, ensuring proper development of the central nervous system and other tissues. Clinical implications of NR6A1 dysregulation include infertility, developmental disorders, and potential roles in cancer. Understanding NR6A1’s regulatory mechanisms is vital for advancing therapeutic strategies targeting related conditions.
nuclear receptor subfamily 6 group A member 1 (NR6A1)
RTR,GCNF,NR61,Hrtr,CT150,GCNF1,hGCNF,Germ cell nuclear factor,Retinoid receptor-related testis-specific receptor
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (ELISA Kits, Primary Antibodies) relacionados con NR6A1 - nuclear receptor subfamily 6 group A member 1
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | NR6A1 | abx535832 | Human Nuclear receptor subfamily 6 group A member 1 (NR6A1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q15406 | RUO | ||
Abbexa | NR6A1 | abx535833 | Mouse Nuclear receptor subfamily 6 group A member 1 (NR6A1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q64249 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | NR6A1 | abx012122 | Nuclear Receptor Subfamily 6 Group A Member 1 (NR6A1) Antibody | Human | Monoclonal | Mouse | Nuclear Receptor Subfamily 6 Group A Member 1 (NR6A1) | Unconjugated | ELISA, WB, IHC, IF/ICC, FCM | 362.5 | 100 µl | Q15406 | RUO | |
Abbexa | NR6A1 | abx376047 | Nuclear Receptor Subfamily 6 Group A Member 1 (NR6A1) Antibody | Human | Polyclonal | Rabbit | Nuclear Receptor Subfamily 6 Group A Member 1 (NR6A1) | Unconjugated | ELISA, WB | 337.5 | 100 µg | Q15406 | RUO | |
Abbexa | NR6A1 | abx026203 | Nuclear Receptor Subfamily 6 Group A Member 1 (NR6A1) Antibody | Human | Polyclonal | Rabbit | Nuclear Receptor Subfamily 6 Group A Member 1 (NR6A1) | Unconjugated | ELISA, WB | 250 | 80 µl | Q15406 | RUO | |
Abbexa | NR6A1 | abx114201 | Nuclear Receptor Subfamily 6, Group A, Member 1 (NR6A1) Antibody | Human | Polyclonal | Rabbit | Nuclear Receptor Subfamily 6, Group A, Member 1 (NR6A1) | Unconjugated | ELISA, WB | 612.5 | 100 µl | Q15406 | RUO | |
Abbexa | NR6A1 | abx233390 | Nuclear Receptor Subfamily 6 Group A Member 1 (NR6A1) Antibody | Human | Polyclonal | Rabbit | Nuclear Receptor Subfamily 6 Group A Member 1 (NR6A1) | Unconjugated | ELISA, WB, IHC, IP | 350 | 100 µg | Q15406 | RUO |
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