Family main features
Neuronal Growth Regulator 1 (NEGR1) is a protein encoded by the NEGR1 gene, located on chromosome 1p31.1. This gene is part of the immunoglobulin (Ig) superfamily and is known to play critical roles in neural development and plasticity. NEGR1 is involved in cell-cell adhesion, promoting neurite outgrowth, and synapse formation, which are crucial processes for the proper functioning of the nervous system. The protein has garnered interest due to its association with neuropsychiatric disorders and obesity, highlighting its potential role in brain function and metabolism.
NEGR1 is a glycosylphosphatidylinositol (GPI)-anchored protein, indicating it is tethered to the cell membrane via a GPI anchor rather than spanning the membrane with transmembrane domains. The primary structure of NEGR1 includes three immunoglobulin-like (Ig-like) domains, which are typical of proteins involved in cell adhesion and signaling. These domains facilitate homophilic (self-binding) and heterophilic (binding to other molecules) interactions essential for its function in neural connectivity and plasticity.
NEGR1 belongs to the IgLON family of neural cell adhesion molecules, which also includes OPCML, LSAMP, and HNT. These proteins share structural similarities and are implicated in similar biological processes, primarily involving neural development and synaptic plasticity.
NEGR1 is crucial for several key biological processes:
Alterations in NEGR1 expression or function have been associated with various clinical conditions:
NEGR1 is a vital protein within the IgLON family, contributing to neural development, synaptic plasticity, and cell adhesion. It plays critical roles in neurite outgrowth, synapse formation, and possibly, metabolic regulation. Clinical studies have linked NEGR1 to neuropsychiatric disorders and obesity, underscoring its significance in brain function and overall health. Understanding NEGR1's molecular mechanisms and pathways can provide insights into its diverse biological functions and potential therapeutic targets for related diseases.
neuronal growth regulator 1 (NEGR1)
Ntra,KILON,IGLON4,DMML2433,IgLON family member 4
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits) relacionados con NEGR1 - neuronal growth regulator 1
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | NEGR1 | EH14985 | Human NEGR1(Neuronal growth regulator 1) ELISA Kit | human | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 78.125-5000pg/ml | 96T | Q7Z3B1 | RUO | ||
Abbexa | NEGR1 | abx385212 | Human Neuronal growth regulator 1 (NEGR1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 46.9 pg/ml | 687.5 | 96 tests | Q7Z3B1 | RUO |
Abbexa | NEGR1 | abx390026 | Mouse Neuronal Growth Regulator 1 (NEGR1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | < 13.5 pg/ml | 687.5 | 96 tests | Q80Z24 | RUO |
Abbexa | NEGR1 | abx391694 | Rat Neuronal growth regulator 1 (NEGR1) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 46.9 pg/ml | 687.5 | 96 tests | Q9Z0J8 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | NEGR1 | abx302641 | Neuronal Growth Regulator 1 (NEGR1) Antibody | Human | Polyclonal | Rabbit | Neuronal Growth Regulator 1 (NEGR1) | Unconjugated | ELISA, WB, IHC, IF/ICC | 162.5 | 20 µg | Q7Z3B1 | RUO | |
Abbexa | NEGR1 | abx029178 | Neuronal Growth Regulator 1 (NEGR1) Antibody | Human | Polyclonal | Rabbit | Neuronal Growth Regulator 1 (NEGR1) | Unconjugated | ELISA, WB | 281.25 | 80 µl | Q7Z3B1 | RUO | |
Abbexa | NEGR1 | abx327618 | Neuronal growth regulator 1 (NEGR1) Antibody | Human | Polyclonal | Rabbit | Neuronal growth regulator 1 (NEGR1) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q7Z3B1 | RUO | |
Abbexa | NEGR1 | abx119119 | Neuronal Growth Regulator 1 (NEGR1) Antibody | Human | Polyclonal | Rabbit | Neuronal Growth Regulator 1 (NEGR1) | Unconjugated | WB | 43.75 | 10 µg | Q7Z3B1 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | NEGR1 | abx692158 | Human Neuronal Growth Regulator 1 (NEGR1) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 100 µg | RUO | ||
Abbexa | NEGR1 | abx691605 | Mouse Neuronal Growth Regulator 1 (NEGR1) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 962.5 | 100 µg | RUO |
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