Family main features
Kalirin (KALRN) is a multidomain protein encoded by the KALRN gene, which plays a crucial role in neuronal development and function. It belongs to the Rho guanine nucleotide exchange factor (RhoGEF) family and is involved in the regulation of cytoskeletal dynamics. This protein is highly expressed in the nervous system, particularly in the brain, where it influences processes such as synaptic plasticity, dendritic spine morphogenesis, and axonal guidance. Disruption in KALRN function has been implicated in various neurological and psychiatric disorders, including schizophrenia, autism spectrum disorders, and Alzheimer's disease.
Kalirin is a large and complex protein with multiple isoforms generated through alternative splicing. The structure of Kalirin includes several important domains:
The combination of these domains allows Kalirin to act as a multifunctional scaffold protein that can integrate various signaling pathways to regulate cytoskeletal dynamics and cellular morphology.
Kalirin has multiple isoforms, the most notable being:
Each isoform has specific roles depending on its structural domains and the tissues in which it is expressed.
Kalirin's primary functions are related to its role as a RhoGEF and its ability to interact with various signaling proteins. Key functions include:
Mutations or dysregulation of Kalirin are associated with several neurological and psychiatric disorders:
Kalirin is a multifaceted protein crucial for neuronal development and function. Its various domains allow it to act as a scaffold and regulator of cytoskeletal dynamics, influencing processes such as synaptic plasticity, axonal guidance, and cell signaling. The multiple isoforms of Kalirin, each with specific roles, highlight its importance in maintaining neuronal and cellular function. Dysregulation or mutations in Kalirin are linked to several neurological and psychiatric disorders, underscoring its significance in brain health and disease. Understanding the molecular mechanisms of Kalirin's function can provide insights into potential therapeutic targets for these conditions.
kalirin RhoGEF kinase (KALRN)
DUO,CHD5,DUET,TRAD,CHDS5,HAPIP,KALNC2,ARHGEF24,Kalirin,Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain,Huntingtin-associated protein-interacting protein
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Primary Antibodies, ELISA Kits) relacionados con KALRN - kalirin RhoGEF kinase
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 11 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
Contacta con nosotros en info@markelab.com, si necesitas mas informacion o alguna aclaracion. Te garantizamos respuesta en menos de 24 h.
provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | KALRN | abx388064 | Human Kalirin (KALRN) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 22 pg/ml | 687.5 | 96 tests | O60229 | RUO |
Abbexa | KALRN | abx389678 | Mouse Kalirin (KALRN) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | < 10 pg/ml | 687.5 | 96 tests | A2CG49 | RUO |
Abbexa | KALRN | abx391518 | Rat Kalirin (KALRN) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 46.9 pg/ml | 687.5 | 96 tests | P97924 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | KALRN | FNab04462 | anti- KALRN antibody | human | polyclonal | Rabbit | kalirin, RhoGEF kinase | IgG | Unconjugated | ELISA, WB | 100µg | O60229 | RUO | |
Abbexa | KALRN | abx113303 | Kalirin (KALRN) Antibody | Human | Polyclonal | Rabbit | Kalirin (KALRN) | Unconjugated | ELISA, WB | 612.5 | 100 µl | O60229 | RUO | |
Abbexa | KALRN | abx343641 | Kalirin (KALRN) Antibody | Human | Polyclonal | Rabbit | Kalirin (KALRN) | Unconjugated | ELISA, IHC, IF/ICC | 250 | 50 µl | O60229 | RUO | |
Abbexa | KALRN | abx343642 | Kalirin (KALRN) Antibody (HRP) | Human | Polyclonal | Rabbit | Kalirin (KALRN) | HRP | ELISA | 250 | 50 µl | O60229 | RUO | |
Abbexa | KALRN | abx343643 | Kalirin (KALRN) Antibody (FITC) | Human | Polyclonal | Rabbit | Kalirin (KALRN) | FITC | 250 | 50 µl | O60229 | RUO | ||
Abbexa | KALRN | abx343644 | Kalirin (KALRN) Antibody (Biotin) | Human | Polyclonal | Rabbit | Kalirin (KALRN) | Biotin | ELISA | 250 | 50 µl | O60229 | RUO | |
Abbexa | KALRN | abx234462 | Kalirin (KALRN) Antibody | Human | Polyclonal | Rabbit | Kalirin (KALRN) | Unconjugated | ELISA, WB | 350 | 100 µg | O60229 | RUO | |
Abbexa | KALRN | abx327546 | Kalirin (KALRN) Antibody | Human | Polyclonal | Rabbit | Kalirin (KALRN) | Unconjugated | ELISA, WB | 187.5 | 50 µg | O60229 | RUO |
Te recomendamos que si no encuentras lo que buscas, utilices el buscador, refinando la búsqueda según tu criterio y usando Alias, o bien contacta con nosotros.