Mouse Kalirin (KALRN) ELISA Kit
715€ (96 tests)
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935106861
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name
Mouse Kalirin (KALRN) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx389678
tested applications
ELISA
Description
Mouse Kalirin (KALRN) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse KALRN concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Kalirin (KALRN) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 31.2 pg/ml - 2000 pg/ml |
| Sensitivity | < 10 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | A2CG49 |
| Gene ID | 545156 |
| Alias | DUO,CHD5,DUET,TRAD,CHDS5,HAPIP,KALNC2,ARHGEF24,Kalirin,Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain,Huntingtin-associated protein-interacting protein |
| Background | Elisa kits for KALRN |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Kalirin RhoGEF Kinase (KALRN) is a multifunctional protein that acts as a Rho guanine nucleotide exchange factor (RhoGEF), playing a critical role in regulating cytoskeletal dynamics, neuronal development, and synaptic plasticity. KALRN is expressed predominantly in the central nervous system (CNS), particularly in neurons, where it facilitates the remodeling of the actin cytoskeleton to regulate axon growth, dendritic spine formation, and synaptic connectivity. Structurally, KALRN contains multiple domains, including RhoGEF domains that activate Rho family GTPases, such as Rac1 and RhoA, SH3 and PH domains for protein-protein and membrane interactions, and a kinase domain that adds signaling versatility. This complex structure enables KALRN to integrate signals from various upstream pathways and regulate cytoskeletal dynamics critical for neuronal morphology. KALRN is essential for brain development and cognitive processes, including learning and memory, by modulating the size and shape of dendritic spines. It interacts with receptors like NMDARs (N-methyl-D-aspartate receptors) and TrkB (tropomyosin receptor kinase B), linking extracellular cues to intracellular cytoskeletal changes. KALRN is also involved in vascular remodeling, where it regulates endothelial cell migration and angiogenesis.
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