Family main features
Interleukin-7 (IL-7) is a critical cytokine primarily involved in the development, survival, and homeostasis of immune cells, particularly T cells and B cells. It plays an essential role in lymphopoiesis, ensuring the proper function and maintenance of the adaptive immune system. IL-7 is produced mainly by stromal cells in the bone marrow and thymus, but it is also secreted by epithelial cells in other tissues, such as the intestines, liver, and skin. Unlike many cytokines, IL-7 is not produced by immune cells themselves but acts as a growth factor necessary for immune cell survival and proliferation.
IL-7 is vital for the survival of naïve and memory T cells, supporting the homeostasis of these populations throughout life. It also supports the early stages of B cell development in the bone marrow and ensures the development of a healthy and functional immune system. IL-7’s function in maintaining T cell homeostasis and supporting immune recovery has made it a target of interest in immunotherapy, particularly for treating immune deficiencies, enhancing cancer immunotherapy, and facilitating immune reconstitution in HIV patients.
IL-7 is a small glycoprotein with a molecular weight of approximately 25 kDa, consisting of 177 amino acids. The structure of IL-7 is characterized by a four-helix bundle typical of the class I cytokine family, which also includes IL-2, IL-4, and IL-9. This cytokine adopts a compact, globular shape supported by two disulfide bonds that are essential for maintaining its structural integrity and biological activity.
Key elements of IL-7’s structure include:
The interaction of IL-7 with IL-7Rα initiates the recruitment of the γc subunit, leading to receptor dimerization and activation of intracellular signaling pathways, primarily the JAK/STAT (Janus kinase/Signal Transducer and Activator of Transcription) pathway. This signaling cascade is crucial for the promotion of cell survival, proliferation, and differentiation.
IL-7 is a member of the class I cytokine family, which is characterized by cytokines that adopt a four-helix bundle structure and signal through receptors containing the common gamma chain (γc). IL-7 is classified as a hematopoietic growth factor due to its role in lymphocyte development and homeostasis.
Though IL-7 does not have distinct subtypes, it shares functional similarities with other cytokines like:
IL-7 is indispensable for the immune system, with its primary biological functions focused on the development and maintenance of T cells and B cells. Key roles of IL-7 include:
Given its central role in lymphocyte biology, dysregulation of IL-7 or its signaling pathways can lead to various clinical issues, particularly in immune deficiencies, autoimmune diseases, and cancers. Therapeutic modulation of IL-7 has emerged as a potential strategy for treating these conditions.
IL-7 is a crucial cytokine involved in the development, survival, and homeostasis of T and B cells, with a particular focus on lymphocyte survival during immune development and homeostasis. Structurally, it is a small glycoprotein characterized by a four-helix bundle and stabilized by disulfide bonds, which bind to the IL-7 receptor complex composed of IL-7Rα and the common gamma chain (γc). Functionally, IL-7 is indispensable for T cell development in the thymus, B cell maturation in the bone marrow, and the maintenance of naïve and memory T cells in peripheral circulation. Clinically, IL-7 dysregulation is linked to immune deficiencies like SCID, autoimmune diseases, and it has therapeutic potential in immunodeficiency recovery, cancer immunotherapy, and HIV treatment. Understanding the biological role of IL-7 has opened new avenues for targeted therapies aimed at modulating immune responses in both disease and therapeutic contexts.
interleukin 7 (IL7)
IL-7
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con IL7 - interleukin 7
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 54 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | IL7 | abx513643 | Cow Interleukin 7 (IL7) ELISA Kit | Cow | Serum,Plasma,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | P26895 | RUO | ||
FineTest | IL7 | EH0203 | Human IL-7(Interleukin 7) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 7.813-500pg/ml | 96T | P13232 | RUO | ||
Abbexa | IL7 | abx251356 | Human Interleukin 7 (IL7) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 7.81 pg/ml - 500 pg/ml | 4.69 pg/ml | 525 | 96 tests | P13232 | RUO |
Abbexa | IL7 | abx491843 | Human Interleukin 7 (IL7) CLIA Kit | Human | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 15.62 pg/ml - 1000 pg/ml | < 5.8 pg/ml | 812.5 | 96 tests | P13232, A0A0A0MTG5, D0EYG7 | RUO |
Abbexa | IL7 | abx052090 | Low Sample Volume Human Interleukin 7 (IL7) ELISA Kit | Human | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 6.1 pg/ml | 737.5 | 96 tests | P13232, A0A0A0MTG5, D0EYG7 | RUO |
Abbexa | IL7 | abx195913 | Human Interleukin 7 (IL7) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 7.81 pg/ml - 500 pg/ml | 4.69 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | IL7 | abx152048 | Human Interleukin 7 (IL7) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 5.9 pg/ml | 618.75 | 96 tests | P13232, A0A0A0MTG5, D0EYG7 | RUO |
FineTest | IL7 | EM0122 | Mouse IL-7(Interleukin 7) ELISA Kit | mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 15.625-1000pg/ml | 96T | P10168 | RUO | ||
Abbexa | IL7 | abx050128 | Mouse Interleukin 7 (IL7) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | 9.38 pg/ml | 493.75 | 96 tests | P10168 | RUO |
Abbexa | IL7 | abx491844 | Mouse Interleukin 7 (IL7) CLIA Kit | Mouse | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 6.2 pg/ml | 812.5 | 96 tests | P10168, Q3UT18 | RUO |
Abbexa | IL7 | abx052091 | Low Sample Volume Mouse Interleukin 7 (IL7) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 6.2 pg/ml | 750 | 96 tests | P10168, Q3UT18 | RUO |
Abbexa | IL7 | abx154259 | Mouse Interleukin 7 (IL7) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 6.2 pg/ml | 618.75 | 96 tests | P10168, Q3UT18 | RUO |
Abbexa | IL7 | abx195914 | Mouse Interleukin 7 (IL7) CLIA Kit | Mouse | Serum, plasma and other biological fluids. | Sandwich | 7.81 pg/ml - 500 pg/ml | 4.69 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | IL7 | abx257366 | Pig Interleukin 7 (IL7) ELISA Kit | Pig | Serum,Plasma,Other biological fluids | 15.6 pg/ml - 1000 pg/ml | 687.5 | 96 tests | Q9N2G6 | RUO | ||
FineTest | IL7 | EP0179 | Porcine IL-7(Interleukin 7) ELISA Kit | porcine | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 31.25-2000pg/ml | 96T | Q9N2G6 | RUO | ||
FineTest | IL7 | ER0146 | Rat IL-7(Interleukin-7) ELISA Kit | rat | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 15.625-1000pg/ml | 96T | P56478 | RUO | ||
Abbexa | IL7 | abx155738 | Rat Interleukin 7 (IL7) ELISA Kit | Rat | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 5.5 pg/ml | 675 | 96 tests | P56478, F7FJK6, Q91Y32 | RUO |
Abbexa | IL7 | abx574532 | Rat Interleukin 7 (IL7) ELISA Kit | Rat | Serum,Plasma,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | 9.38 pg/ml | 525 | 96 tests | P56478 | RUO |
Abbexa | IL7 | abx195915 | Rat Interleukin 7 (IL7) CLIA Kit | Rat | Serum, plasma and other biological fluids. | Sandwich | 7.81 pg/ml - 500 pg/ml | 4.69 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | IL7 | abx052092 | Low Sample Volume Rat Interleukin 7 (IL7) ELISA Kit | Rat | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 5.5 pg/ml | 787.5 | 96 tests | P56478, F7FJK6, Q91Y32 | RUO |
Abbexa | IL7 | abx491845 | Rat Interleukin 7 (IL7) CLIA Kit | Rat | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 15.62 pg/ml - 1000 pg/ml | < 6.1 pg/ml | 812.5 | 96 tests | P56478, F7FJK6, Q91Y32 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | IL7 | FNab10140 | anti- IL-7 antibody | human | monoclonal | Mouse | interleukin 7 | IgG2b | Unconjugated | ELISA, WB, IHC, IF, FC | 100µg | P13232 | RUO | |
Abbexa | IL7 | abx128922 | Interleukin 7 (IL7) Antibody | Human | Polyclonal | Rabbit | Interleukin 7 (IL7) | Unconjugated | WB, IHC, IF/ICC | 250 | 100 µl | P13232 | RUO | |
Abbexa | IL7 | abx173187 | Interleukin 7 (IL7) Antibody | Human | Monoclonal | Mouse | Interleukin 7 (IL7) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO | ||
Abbexa | IL7 | abx137022 | Interleukin 7 (IL7) Antibody | Human | Monoclonal | Mouse | Interleukin 7 (IL7) | Unconjugated | 487.5 | 0.5 mg | RUO | |||
Abbexa | IL7 | abx234285 | Interleukin 7 (IL7) Antibody | Human | Monoclonal | Mouse | Interleukin 7 (IL7) | Unconjugated | ELISA, WB, IHC, IF/ICC, FCM | 350 | 100 µg | P13232 | RUO | |
Abbexa | IL7 | abx001389 | Interleukin 7 (IL7) Antibody | Human | Polyclonal | Rabbit | Interleukin 7 (IL7) | Unconjugated | WB | 175 | 20 µl | P13232 | RUO | |
Abbexa | IL7 | abx117134 | Interleukin 7 (IL7) Antibody | Human | Polyclonal | Rabbit | Interleukin 7 (IL7) | Unconjugated | ELISA, WB, IHC | 25 | 5 µg | P13232 | RUO | |
Abbexa | IL7 | abx273983 | Interleukin 7 (IL7) Antibody (FITC) | Mouse | Polyclonal | Rabbit | Interleukin 7 (IL7) | FITC | WB, IHC, IF/ICC | 412.5 | 200 µl | RUO | ||
Abbexa | IL7 | abx177197 | Interleukin 7 (IL7) Antibody | Mouse | Polyclonal | Rabbit | Interleukin 7 (IL7) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO | ||
Abbexa | IL7 | abx100959 | Interleukin 7 (IL7) Antibody | Mouse | Polyclonal | Rabbit | Interleukin 7 (IL7) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P10168 | RUO | |
Abbexa | IL7 | abx272727 | Interleukin 7 (IL7) Antibody (Biotin) | Mouse | Polyclonal | Rabbit | Interleukin 7 (IL7) | Biotin | WB, IHC, IF/ICC | 337.5 | 200 µl | RUO | ||
Abbexa | IL7 | abx129989 | Interleukin 7 (IL7) Antibody | Rabbit | Polyclonal | Guinea pig | Interleukin 7 (IL7) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | IL7 | abx263129 | Human Interleukin 7 (IL7) Protein | Human | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | P13232 | RUO | |
FineTest | IL7 | P4735 | Recombinant Human IL-7 | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | P13232 | RUO | ||
FineTest | IL7 | P1835 | Recombinant Human IL7 | Human | Recombinant | E.Coli | Western Blot, ELISA | 50μg | P13232 | RUO | ||
FineTest | IL7 | P5417 | Recombinant Rat IL-7 | Rat | Recombinant | E.Coli | Western Blot,ELISA | 50μg | P56478 | RUO | ||
Abbexa | IL7 | abx262232 | Human Interleukin 7 (IL7) Protein | Human | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | P13232 | RUO | |
Abbexa | IL7 | abx670174 | Human Interleukin 7 (IL7) Protein | Human | E. coli | Unconjugated | ELISA, WB | 462.5 | 10 µg | P13232 | RUO | |
Abbexa | IL7 | abx694120 | Human Interleukin 7 (IL7) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 300 | 20 µg | P13232 | RUO | |
Abbexa | IL7 | abx682041 | Human Interleukin 7 (IL7) Protein | Human | Recombinant | E. coli | Unconjugated | SDS-PAGE | 325 | 10 µg | P13232 | RUO |
Abbexa | IL7 | abx651401 | Human Interleukin 7 (IL7) Protein (Active) | Human | Unconjugated | WB, SDS-PAGE | 650 | 50 µg | P13232 | RUO | ||
Abbexa | IL7 | abx168555 | Rabbit Interleukin 7 (IL7) Protein | Rabbit | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 425 | 50 µg | RUO | |
Abbexa | IL7 | abx060191 | Human Interleukin 7 (IL7) Protein | Human | Recombinant | E. coli | Unconjugated | HPLC, SDS-PAGE | 262.5 | 10 µg | P13232 | RUO |
Abbexa | IL7 | abx262220 | Rat Interleukin 7 (IL7) Protein | Rat | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | P56478 | RUO | |
Abbexa | IL7 | abx654058 | Rat Interleukin 7 (IL7) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | RUO | |
FineTest | IL7 | P4661 | Recombinant Mouse IL-7 | Mouse | Recombinant | E.Coli | Western Blot,ELISA | 50μg | P10168 | RUO | ||
Abbexa | IL7 | abx165560 | Rabbit Interleukin 7 (IL7) Peptide (OVA) | Rabbit | Synthetic | OVA | WB, SDS-PAGE | 475 | 100 µg | RUO | ||
Abbexa | IL7 | abx262163 | Human Interleukin 7 (IL7) Protein | Human | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | P13232 | RUO | |
Abbexa | IL7 | abx262194 | Human Interleukin 7 (IL7) Protein | Human | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | P13232 | RUO | |
Abbexa | IL7 | abx654059 | Mouse Interleukin 7 (IL7) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 287.5 | 10 µg | RUO | |
Abbexa | IL7 | abx067550 | Mouse Interleukin 7 (IL7) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | P10168 | RUO |
Abbexa | IL7 | abx167126 | Human Interleukin 7 (IL7) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO | |
Abbexa | IL7 | abx262241 | Mouse Interleukin 7 (IL7) Protein | Mouse | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | P10168 | RUO |
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