Human Interleukin 7 (IL7) Protein

Product specifications

Proteins and Peptides

Interleukin 7 (IL7)

E. coli

Sequence Fragment: Full length (153 AA.)

ELISA: 0.2-0.4 ng/well, WB: 1.5-3.0 ng/lane, Functional Assays: 0.1-10 ng/ml. Optimal dilutions/concentrations should be determined by the end user.

Human

Unconjugated

17.5 kDa

> 98% (SDS-PAGE and HPLC)

10 µg

Lyophilized

ELISA, WB

Prior to lyophilization: 10 mM Acetic Acid. Does not contain preservatives.

Shipped within 3-7 working days.

Store lyophilized at -20 °C. After reconstitution, aliquot and store undiluted at -20 °C for up to 3 months. Avoid repeated freeze/thaw cycles.

No

P13232

IL-7

Protein IL7

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Reconstitute in 0.1 ml distilled water to obtain a protein concentration of 0.1 mg/ml. For extended storage, it is recommended to add 0.1% BSA. Gently mix after reconstitution.
Endotoxin Level: < 0.1 ng/µg
If a precipitate is visible, we recommend microcentrifugation before use.

Descripción

Interleukin-7 (IL7) is a critical cytokine primarily involved in the development, survival, and homeostasis of immune cells, particularly T cells and B cells. It plays an essential role in lymphopoiesis, ensuring the proper function and maintenance of the adaptive immune system. IL-7 is produced mainly by stromal cells in the bone marrow and thymus, but it is also secreted by epithelial cells in other tissues, such as the intestines, liver, and skin. Unlike many cytokines, IL-7 is not produced by immune cells themselves but acts as a growth factor necessary for immune cell survival and proliferation. IL-7 is vital for the survival of naïve and memory T cells, supporting the homeostasis of these populations throughout life. It also supports the early stages of B cell development in the bone marrow and ensures the development of a healthy and functional immune system. IL-7’s function in maintaining T cell homeostasis and supporting immune recovery has made it a target of interest in immunotherapy, particularly for treating immune deficiencies, enhancing cancer immunotherapy, and facilitating immune reconstitution in HIV patients.

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