Family main features
Interleukin 33 (IL-33) is a member of the IL-1 cytokine family and functions as an alarmin, which means it is released upon cellular damage to alert the immune system to tissue injury or infection. IL-33 is primarily expressed in the nuclei of various structural cells, including endothelial cells, epithelial cells, fibroblasts, and some immune cells. Unlike other cytokines, IL-33 is pre-formed and stored in the nucleus, where it binds to chromatin. Upon cellular damage or necrosis, IL-33 is rapidly released into the extracellular space, where it can exert its pro-inflammatory effects. It binds to the ST2 receptor (a member of the IL-1 receptor family), triggering a signaling cascade that involves MyD88, IRAKs, and TRAF6, leading to the activation of NF-κB and MAPKs pathways. This ultimately results in the production of various pro-inflammatory cytokines and chemokines.
IL-33 is synthesized as a 30 kDa precursor protein, consisting of:
The full-length precursor form can act intracellularly in the nucleus, while the cleaved form acts extracellularly by binding to the ST2 receptor.
IL-33 belongs to the IL-1 cytokine family, which also includes IL-1α, IL-1β, IL-18, and IL-36. The ST2 receptor exists in two forms: a membrane-bound form (ST2L) which mediates signaling, and a soluble form (sST2) which acts as a decoy receptor, modulating the availability and activity of IL-33.
IL-33 plays several key roles in the immune system:
Dysregulation of IL-33 is implicated in various pathological conditions:
Interleukin 33 (IL-33) is a multifunctional cytokine belonging to the IL-1 family, playing critical roles in immune and inflammatory responses. It functions as an alarmin, alerting the immune system to tissue damage and promoting inflammation. IL-33 binds to the ST2 receptor, activating signaling pathways that result in the production of pro-inflammatory mediators. Dysregulation of IL-33 is linked to a variety of diseases, including allergic, autoimmune, cardiovascular, and infectious diseases. Understanding the mechanisms and roles of IL-33 in health and disease provides valuable insights into potential therapeutic targets for treating related conditions.
Interleukin 33 (IL33)
IL33,IL-33,C9orf26,IL1F11,IL-1F11
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con IL33 - Interleukin 33
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 66 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | IL33 | abx519019 | Dog Interleukin 33 (IL33) ELISA Kit | Dog | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | O97863 | RUO | ||
FineTest | IL33 | AQ-H0198-B | Human HS-IL-33(High sensitive Interleukin 33) Accquant® ELISA Kit | human | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 3.1-200pg/ml | 96T | RUO | |||
FineTest | IL33 | EH0198 | Human IL-33(Interleukin-33) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 15.625-1000pg/ml | 96T | O95760 | RUO | ||
Abbexa | IL33 | abx251303 | Human Interleukin 33 (IL33) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | 9.38 pg/ml | 493.75 | 96 tests | O95760 | RUO |
Abbexa | IL33 | abx152042 | Human Interleukin 33 (IL33) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 6.4 pg/ml | 662.5 | 96 tests | O95760 | RUO |
Abbexa | IL33 | abx190282 | Human Interleukin 33 (IL33) CLIA Kit | Human | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 1.37 pg/ml - 1000 pg/ml | < 0.55 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | IL33 | abx197193 | Human Interleukin 33 (IL33) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 7.81 pg/ml - 500 pg/ml | 4.69 pg/ml | 618.75 | 96 tests | RUO | |
FineTest | IL33 | EM0118 | Mouse IL-33(Interleukin 33) ELISA Kit | mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 15.625-1000pg/ml | 96T | Q8BVZ5 | RUO | ||
Abbexa | IL33 | abx254236 | Mouse Interleukin 33 (IL33) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | 9.38 pg/ml | 493.75 | 96 tests | Q8BVZ5 | RUO |
Abbexa | IL33 | abx519021 | Low Sample Volume Mouse Interleukin 33 (IL33) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 7.8 pg/ml - 500 pg/ml | < 3.2 pg/ml | 787.5 | 96 tests | Q8BVZ5, H3BLN5, H3BKB5, D3Z6T7, E9M2E8 | RUO |
Abbexa | IL33 | abx190556 | Mouse Interleukin 33 (IL33) CLIA Kit | Mouse | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 1.37 pg/ml - 1000 pg/ml | < 0.61 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | IL33 | abx154253 | Mouse Interleukin 33 (IL33) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 7.8 pg/ml - 500 pg/ml | < 3.2 pg/ml | 675 | 96 tests | Q8BVZ5, H3BLN5, H3BKB5, D3Z6T7, E9M2E8 | RUO |
FineTest | IL33 | ER1903 | Rat IL-33(Interleukin-33) ELISA Kit | rat | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 15.625-1000pg/ml | 96T | Q66H70 | RUO | ||
Abbexa | IL33 | abx585402 | Rat Interleukin 33 (IL33) ELISA Kit | Rat | Serum,Plasma,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 5.8 pg/ml | 687.5 | 96 tests | Q66H70, A0A096MIT4 | RUO |
Abbexa | IL33 | abx155733 | Rat Interleukin 33 (IL33) ELISA Kit | Rat | Serum,Plasma,Other biological fluids | Sandwich | 7.8 pg/ml - 500 pg/ml | < 3.0 pg/ml | 700 | 96 tests | Q66H70, A0A096MIT4 | RUO |
Abbexa | IL33 | abx576220 | Rat Interleukin 33 (IL33) ELISA Kit | Rat | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | 493.75 | 96 tests | Q66H70 | RUO | |
Abbexa | IL33 | abx190732 | Rat Interleukin 33 (IL33) CLIA Kit | Rat | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 1.37 pg/ml - 1000 pg/ml | < 0.54 pg/ml | 812.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | IL33 | FNab04272 | anti- IL33 antibody | human | monoclonal | Mouse | interleukin 33 | IgG1 | Unconjugated | ELISA, IHC, WB | 100µg | O95760 | RUO | |
FineTest | IL33 | FNab04271 | anti- IL33 antibody | human | polyclonal | Rabbit | interleukin 33 | IgG | Unconjugated | ELISA, IHC, WB | 100µg | O95760 | RUO | |
Abbexa | IL33 | abx234272 | Interleukin 33 (IL33) Antibody | Human | Monoclonal | Mouse | Interleukin 33 (IL33) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | O95760 | RUO | |
Abbexa | IL33 | abx314190 | Interleukin 33 (IL33) Antibody (Biotin) | Human | Polyclonal | Rabbit | Interleukin 33 (IL33) | Biotin | ELISA | 162.5 | 20 µg | O95760 | RUO | |
Abbexa | IL33 | abx314188 | Interleukin 33 (IL33) Antibody (HRP) | Human | Polyclonal | Rabbit | Interleukin 33 (IL33) | HRP | ELISA | 162.5 | 20 µg | O95760 | RUO | |
Abbexa | IL33 | abx314189 | Interleukin 33 (IL33) Antibody (FITC) | Human | Polyclonal | Rabbit | Interleukin 33 (IL33) | FITC | 162.5 | 20 µg | O95760 | RUO | ||
Abbexa | IL33 | abx302100 | Interleukin 33 (IL33) Antibody | Human | Polyclonal | Rabbit | Interleukin 33 (IL33) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | O95760 | RUO | |
Abbexa | IL33 | abx272225 | Interleukin 33 (IL33) Antibody (Biotin) | Human | Polyclonal | Rabbit | Interleukin 33 (IL33) | Biotin | WB, IHC, IF/ICC | 350 | 200 µl | RUO | ||
Abbexa | IL33 | abx370596 | Interleukin 33 (IL33) Antibody Pair | Human | Interleukin 33 (IL33) | ELISA | 1275 | 5 × 96 tests | RUO | |||||
Abbexa | IL33 | abx131858 | Interleukin 33 (IL33) Antibody | Human | Monoclonal | Mouse | Interleukin 33 (IL33) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | O95760 | RUO | |
Abbexa | IL33 | abx131857 | Interleukin 33 (IL33) Antibody | Human | Monoclonal | Mouse | Interleukin 33 (IL33) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | O95760 | RUO | |
Abbexa | IL33 | abx027997 | Interleukin 33 (IL33) Antibody | Human | Polyclonal | Rabbit | Interleukin 33 (IL33) | Unconjugated | ELISA, WB | 250 | 80 µl | O95760 | RUO | |
Abbexa | IL33 | abx116853 | Interleukin 33 (IL33) Antibody | Human | Polyclonal | Rabbit | Interleukin 33 (IL33) | Unconjugated | ELISA, WB | 612.5 | 100 µl | O95760 | RUO | |
Abbexa | IL33 | abx323729 | Interleukin 33 (IL33) Antibody | Human | Polyclonal | Rabbit | Interleukin 33 (IL33) | Unconjugated | ELISA, WB | 187.5 | 50 µg | O95760 | RUO | |
Abbexa | IL33 | abx101205 | Interleukin 33 (IL33) Antibody | Human | Polyclonal | Rabbit | Interleukin 33 (IL33) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | O95760 | RUO | |
Abbexa | IL33 | abx137222 | Interleukin 33 (IL33) Antibody | Human | Monoclonal | Mouse | Interleukin 33 (IL33) | Unconjugated | 225 | 5 µg | RUO | |||
Abbexa | IL33 | abx274458 | Interleukin 33 (IL33) Antibody (Biotin) | Human | Monoclonal | Mouse | Interleukin 33 (IL33) | Biotin | ELISA, WB, IHC, IF/ICC | 287.5 | 100 µl | RUO | ||
Abbexa | IL33 | abx412008 | Pro-Interleukin 33 (Pro-IL33) Antibody | Human | Polyclonal | Rabbit | Pro-Interleukin 33 (Pro-IL33) | Unconjugated | WB, IF/ICC | 450 | 100 µg | O95760 | RUO | |
Abbexa | IL33 | abx101204 | Interleukin 33 (IL33) Antibody | Human | Polyclonal | Rabbit | Interleukin 33 (IL33) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | O95760 | RUO | |
Abbexa | IL33 | abx131855 | Interleukin 33 (IL33) Antibody | Human | Monoclonal | Mouse | Interleukin 33 (IL33) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | O95760 | RUO | |
Abbexa | IL33 | abx110444 | Interleukin 33 (IL33) Antibody | Human | Polyclonal | Rabbit | Interleukin 33 (IL33) | Unconjugated | ELISA, WB | 162.5 | 20 µg | M5B263 | RUO | |
Abbexa | IL33 | abx123110 | Interleukin 33 (IL33) Antibody | Human | Polyclonal | Rabbit | Interleukin 33 (IL33) | Unconjugated | WB | 175 | 20 µl | O95760 | RUO | |
Abbexa | IL33 | abx234271 | Interleukin 33 (IL33) Antibody | Human | Polyclonal | Rabbit | Interleukin 33 (IL33) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | O95760 | RUO | |
Abbexa | IL33 | abx271245 | Interleukin 33 (IL33) Antibody (FITC) | Mouse | Polyclonal | Rabbit | Interleukin 33 (IL33) | FITC | WB, IHC, IF/ICC | 425 | 200 µl | RUO | ||
Abbexa | IL33 | abx101206 | Interleukin 33 (IL33) Antibody | Mouse | Polyclonal | Rabbit | Interleukin 33 (IL33) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q8BVZ5 | RUO | |
Abbexa | IL33 | abx271511 | Interleukin 33 (IL33) Antibody (Biotin) | Mouse | Polyclonal | Rabbit | Interleukin 33 (IL33) | Biotin | WB, IHC, IF/ICC | 362.5 | 200 µl | RUO | ||
Abbexa | IL33 | abx177167 | Interleukin 33 (IL33) Antibody | Mouse | Polyclonal | Rabbit | Interleukin 33 (IL33) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO | ||
Abbexa | IL33 | abx107579 | Interleukin 33 (IL33) Antibody (FITC) | Pig | Polyclonal | Rabbit | Interleukin 33 (IL33) | FITC | 162.5 | 20 µg | M5B263 | RUO | ||
Abbexa | IL33 | abx106166 | Interleukin 33 (IL33) Antibody (Biotin) | Pig | Polyclonal | Rabbit | Interleukin 33 (IL33) | Biotin | ELISA | 162.5 | 20 µg | M5B263 | RUO | |
Abbexa | IL33 | abx108998 | Interleukin 33 (IL33) Antibody (HRP) | Pig | Polyclonal | Rabbit | Interleukin 33 (IL33) | HRP | ELISA | 162.5 | 20 µg | M5B263 | RUO | |
Abbexa | IL33 | abx131856 | Interleukin 33 (IL33) Antibody | Rat | Monoclonal | Mouse | Interleukin 33 (IL33) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | Q66H70 | RUO | |
Abbexa | IL33 | abx101207 | Interleukin 33 (IL33) Antibody | Rat | Polyclonal | Rabbit | Interleukin 33 (IL33) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | Q66H70 | RUO | |
Abbexa | IL33 | abx273279 | Interleukin 33 (IL33) Antibody (Biotin) | Rat | Polyclonal | Rabbit | Interleukin 33 (IL33) | Biotin | WB, IHC, IF/ICC | 375 | 200 µl | RUO | ||
Abbexa | IL33 | abx130203 | Interleukin 33 (IL33) Antibody | Rat | Polyclonal | Rabbit | Interleukin 33 (IL33) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | Q66H70 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | IL33 | P4334 | Recombinant Human IL-33 | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | O95760 | RUO | ||
Abbexa | IL33 | abx262948 | Rat Interleukin 33 (IL33) Protein | Rat | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | Q66H70 | RUO | |
Abbexa | IL33 | abx262957 | Human Interleukin 33 (IL33) Protein | Human | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | O95760 | RUO | |
Abbexa | IL33 | abx262960 | Mouse Interleukin 33 (IL33) Protein | Mouse | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | Q8BVZ5 | RUO | |
FineTest | IL33 | P5916 | Recombinant Human IL-33 | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | Q2YEJ5 | RUO | ||
Abbexa | IL33 | abx067523 | Human Interleukin 33 (IL33) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | O95760 | RUO |
Abbexa | IL33 | abx067526 | Human Interleukin 33 (IL33) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | O95760 | RUO |
FineTest | IL33 | P6137 | Recombinant Mouse IL-33 | Mouse | Recombinant | E.Coli | Western Blot,ELISA | 50μg | Q8BVZ5 | RUO | ||
Abbexa | IL33 | abx168562 | Rat Interleukin 33 (IL33) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | Q66H70 | RUO |
Abbexa | IL33 | abx655734 | Human Interleukin 33 (IL33) Protein (Active) | Human | Recombinant | Unconjugated | WB, SDS-PAGE | 650 | 50 µg | RUO | ||
FineTest | IL33 | P6007 | Recombinant Rat IL-33 | Rat | Recombinant | E.Coli | Western Blot,ELISA | 50μg | Q66H70 | RUO | ||
Abbexa | IL33 | abx067525 | Rat Interleukin 33 (IL33) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | Q66H70 | RUO |
Abbexa | IL33 | abx682004 | Human Interleukin 33 (IL33) Protein | Human | Recombinant | E. coli | Unconjugated | SDS-PAGE | 312.5 | 10 µg | O95760 | RUO |
Abbexa | IL33 | abx262284 | Human Interleukin 33 (IL33) Protein | Human | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | O95760 | RUO | |
Abbexa | IL33 | abx067524 | Mouse Interleukin 33 (IL33) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | RUO |
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