Rat Interleukin 33 (IL33) Protein

Este producto es parte de IL33 - Interleukin 33
Rat Interleukin 33 (IL33) Protein

Pida mas información

935106861

info@markelab.com

Precio

247€ (10 µg)

Protein IL33

proveedor

Abbexa

reference

abx168562

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Interleukin 33 Protein is a recombinant Rat protein expressed in E. coli.


Background

IL33 is a nuclear alarmin cytokine belonging to the IL-1 family, released during cellular stress, injury, or necrosis to alert the immune system and promote inflammation. IL33 binds to its receptor IL1RL1 (ST2) and forms a signaling complex with IL1RAP, leading to activation of NF-κB and MAPK pathways, which drive cytokine production, immune cell activation, and tissue repair. IL33 primarily targets type 2 immune cells, including Th2 cells, innate lymphoid cells (ILC2s), mast cells, and eosinophils, to regulate allergic inflammation, tissue homeostasis, and anti-helminth immunity. It is abundantly expressed in epithelial cells, endothelial cells, and fibroblasts, where it functions as both a cytokine and a transcriptional regulator. Dysregulated IL33 signaling contributes to allergic diseases, such as asthma, atopic dermatitis, and rhinitis, as well as inflammatory and fibrotic disorders. In tumors, IL33 can promote both pro- and anti-tumor immune responses depending on the context. Knockout studies reveal reduced type 2 cytokine production, impaired tissue repair, and weakened immune responses, highlighting IL33’s role in inflammation, tissue homeostasis, and immunity.

Características del producto

category

Proteins and Peptides


origin

Rat


host

E. coli


immunogen target

Interleukin 33 (IL33)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 13.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met5-Leu108 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

IL33


dry ice

No


availability

Shipped within 5-7 working days.


alias

IL33,IL-33,C9orf26,IL1F11,IL-1F11


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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