Family main features
Interleukin 32 (IL-32) is a relatively newly discovered pro-inflammatory cytokine, originally identified in 2005. It is unique because it does not belong to the classical cytokine families, such as the IL-6 or IL-1 families, and its function is primarily associated with the regulation of inflammation. IL-32 is produced by a variety of cell types, including T cells, natural killer (NK) cells, monocytes, macrophages, fibroblasts, epithelial cells, and endothelial cells, underscoring its broad role in immune regulation.
IL-32 expression is induced by other cytokines such as IFN-γ (interferon-gamma), IL-12, IL-18, and TNF-α. Its expression is also elevated in response to pathogen-associated molecular patterns (PAMPs) such as lipopolysaccharides (LPS) found on bacterial surfaces, signifying its role in innate immune responses to infection.
IL-32 is implicated in a variety of chronic inflammatory diseases, including autoimmune disorders, cancer, atherosclerosis, and infectious diseases. Its potent ability to induce other pro-inflammatory cytokines like TNF-α, IL-1β, IL-6, and IL-8 highlights its significance in amplifying immune responses.
IL-32 is a non-glycosylated protein and exists in multiple isoforms due to alternative splicing of its mRNA. These isoforms include IL-32α, IL-32β, IL-32γ, IL-32δ, IL-32ε, IL-32ζ, and IL-32θ. Among these, IL-32γ is considered the most biologically active isoform and is often used in experimental studies.
IL-32 does not belong to any classical cytokine family such as the IL-1 or IL-6 families, making it a unique pro-inflammatory cytokine. However, IL-32 exists in multiple isoforms generated by alternative splicing:
IL-32 plays a significant role in inflammation and immune responses through the induction of pro-inflammatory cytokines and other immune-regulating molecules. Its primary functions are associated with pathogen defense, immune cell activation, and amplifying inflammation in chronic diseases. Some key functions of IL-32 include:
IL-32 has been linked to various chronic inflammatory diseases and immune-related conditions. The high levels of IL-32 observed in several autoimmune disorders, infectious diseases, and cancers suggest that IL-32 plays a pivotal role in modulating immune responses in both acute and chronic settings. Some key clinical issues associated with IL-32 include:
IL-32 is a non-classical cytokine with strong pro-inflammatory properties, playing a significant role in immune regulation, particularly in chronic inflammation, autoimmunity, infection, and cancer. Structurally, IL-32 exists in multiple isoforms, with IL-32γ being the most biologically active. Unlike most cytokines, IL-32 exerts its effects without a specific receptor, instead acting through intracellular signaling pathways. Clinically, IL-32 is implicated in various autoimmune diseases, infectious diseases, and cancers, making it a potential therapeutic target for immune-modulating therapies. Its role in pathogen defense and its association with inflammatory diseases underline its importance as a critical cytokine in immune regulation.
interleukin 32 (IL32)
NK4,TAIF,TAIFa,TAIFb,TAIFc,TAIFd,IL-32beta,IL-32alpha,IL-32delta,IL-32gamma,Natural killer cells protein 4,Tumor necrosis factor alpha-inducing factor
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, CLIA Kits, ELISA Kits) relacionados con IL32 - interleukin 32
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 24 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
Contacta con nosotros en info@markelab.com, si necesitas mas informacion o alguna aclaracion. Te garantizamos respuesta en menos de 24 h.
provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | IL32 | EH1938 | Human IL32(Interleukin-32) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 15.625-1000pg/ml | 96T | P24001 | RUO | ||
Abbexa | IL32 | abx190246 | Human Interleukin 32 (IL32) CLIA Kit | Human | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 1.37 pg/ml - 1000 pg/ml | < 0.54 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | IL32 | abx251258 | Human Interleukin 32 (IL32) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | 9.38 pg/ml | 525 | 96 tests | P24001 | RUO |
Abbexa | IL32 | abx195895 | Human Interleukin 32 (IL32) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 7.81 pg/ml - 500 pg/ml | 4.69 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | IL32 | abx152041 | Human Interleukin 32 (IL32) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 5.9 pg/ml | 662.5 | 96 tests | P24001, E9PK07, F8VSD2, E9PIV2, F8W1V1, F8VVN4 | RUO |
Abbexa | IL32 | abx195896 | Mouse Interleukin 32 (IL32) CLIA Kit | Mouse | Serum, plasma and other biological fluids. | 7.81 pg/ml - 500 pg/ml | 4.69 pg/ml | 618.75 | 96 tests | RUO | ||
Abbexa | IL32 | abx585722 | Low Sample Volume Mouse Interleukin 32 (IL32) ELISA Kit | Mouse | Low Sample | Sandwich | 7.8 pg/ml - 500 pg/ml | 787.5 | 96 tests | RUO | ||
Abbexa | IL32 | abx195897 | Rat Interleukin 32 (IL32) CLIA Kit | Rat | Serum, plasma and other biological fluids. | 7.81 pg/ml - 500 pg/ml | 4.69 pg/ml | 618.75 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | IL32 | FNab04270 | anti- IL32 antibody | human | polyclonal | Rabbit | interleukin 32 | IgG | Unconjugated | ELISA, IHC, WB | 100µg | P24001 | RUO | |
Abbexa | IL32 | abx113254 | Interleukin 32 (IL32) Antibody | Human | Polyclonal | Rabbit | Interleukin 32 (IL32) | Unconjugated | ELISA, IHC | 612.5 | 100 µl | P24001 | RUO | |
Abbexa | IL32 | abx313234 | Interleukin 32 (IL32) Antibody | Human | Polyclonal | Rabbit | Interleukin 32 (IL32) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | P24001 | RUO | |
Abbexa | IL32 | abx313237 | Interleukin 32 (IL32) Antibody (Biotin) | Human | Polyclonal | Rabbit | Interleukin 32 (IL32) | Biotin | ELISA | 162.5 | 20 µg | P24001 | RUO | |
Abbexa | IL32 | abx324604 | Interleukin 32 (IL32) Antibody | Human | Polyclonal | Rabbit | Interleukin 32 (IL32) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | P24001 | RUO | |
Abbexa | IL32 | abx313235 | Interleukin 32 (IL32) Antibody (HRP) | Human | Polyclonal | Rabbit | Interleukin 32 (IL32) | HRP | ELISA | 162.5 | 20 µg | P24001 | RUO | |
Abbexa | IL32 | abx173156 | Interleukin 32 (IL32) Antibody | Human | Monoclonal | Mouse | Interleukin 32 (IL32) | Unconjugated | WB, IHC, IF/ICC | 750 | 1 ml | RUO | ||
Abbexa | IL32 | abx234270 | Interleukin 32 (IL32) Antibody | Human | Polyclonal | Rabbit | Interleukin 32 (IL32) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | P24001 | RUO | |
Abbexa | IL32 | abx313236 | Interleukin 32 (IL32) Antibody (FITC) | Human | Polyclonal | Rabbit | Interleukin 32 (IL32) | FITC | 162.5 | 20 µg | P24001 | RUO | ||
Abbexa | IL32 | abx137221 | Interleukin 32 (IL32) Antibody | Human | Monoclonal | Mouse | Interleukin 32 (IL32) | Unconjugated | 225 | 5 µg | RUO | |||
Abbexa | IL32 | abx177166 | Interleukin 32 (IL32) Antibody | Human | Polyclonal | Rabbit | Interleukin 32 (IL32) | Unconjugated | WB, IHC, IF/ICC | 712.5 | 1 ml | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | IL32 | abx262396 | IL32A Protein | Human | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | P24001 | RUO | |
Abbexa | IL32 | abx652171 | Human Interleukin 32 (IL32) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 250 | 10 µg | P24001 | RUO |
FineTest | IL32 | P4955 | Recombinant Human IL-32 | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | P24001 | RUO | ||
Abbexa | IL32 | abx260740 | IL32A Protein | Human | Recombinant | Unconjugated | SDS-PAGE | 225 | 5 µg | P24001 | RUO | |
Abbexa | IL32 | abx655733 | Human Interleukin 32 (IL32) Protein (Active) | Human | Recombinant | Unconjugated | WB, SDS-PAGE | 2725 | 1 mg | RUO |
Te recomendamos que si no encuentras lo que buscas, utilices el buscador, refinando la búsqueda según tu criterio y usando Alias, o bien contacta con nosotros.