Family main features
Toll-like receptor 10 (TLR10) is the only human TLR with an entirely unknown ligand and functional role, marking it as a unique and enigmatic member of the Toll-like receptor (TLR) family. This family plays essential roles in innate immunity by recognizing pathogen-associated molecular patterns (PAMPs) and initiating immune responses. Despite its unclear ligand specificity, TLR10 is hypothesized to play regulatory roles, particularly in modulating immune responses. In humans, TLR10 is primarily expressed in lymphoid tissues such as the spleen, lymph nodes, tonsils, and the immune cells within these tissues, including B cells, dendritic cells (DCs), and monocytes. TLR10 is expressed alongside TLRs that typically recognize nucleic acids or microbial components, which suggests that it may function in coordination with other TLRs to fine-tune immune responses, potentially acting as a regulatory or inhibitory receptor.
Structurally, TLR10 resembles other TLR family members, with unique features and slight variations that likely influence its regulatory roles. TLR10 has three main structural domains:
Extracellular Domain:
Transmembrane Domain:
Cytoplasmic Toll/Interleukin-1 Receptor (TIR) Domain:
TLR10 is classified within the TLR1 subfamily, which also includes TLR1, TLR2, and TLR6. This subfamily is known for its ability to recognize microbial components such as lipopeptides and other lipid-containing molecules. Despite being part of this family, TLR10 lacks a defined ligand and has structural and functional distinctions that set it apart:
Although its precise function is still under investigation, evidence suggests that TLR10 serves as a modulator of immune responses, likely with inhibitory effects. Some of the key functions and potential biological roles of TLR10 include:
Immune Modulation and Anti-inflammatory Role:
Role in B Cells:
Interaction with TLR2:
Potential Role in Infection and Tolerance:
TLR10’s potential regulatory role makes it a promising target for therapeutic modulation in diseases characterized by excessive inflammation or immune dysregulation:
Autoimmune Diseases:
Chronic Inflammatory Conditions:
Cancer:
Infectious Diseases:
TLR10, part of the Toll-like receptor family, is unique in its lack of a known ligand and apparent role as a modulatory receptor. Its protein structure is similar to other TLRs, with leucine-rich repeats for potential ligand binding, a transmembrane domain, and a conserved cytoplasmic TIR domain that transduces signals. TLR10’s structural ability to form dimers with TLR2 hints at its regulatory capabilities, while its dominant expression in immune cells, particularly B cells, aligns with its hypothesized role in immune modulation.
Functionally, TLR10 is suspected to play an anti-inflammatory role, potentially suppressing NF-κB and MAPK signaling pathways that lead to cytokine production. This characteristic positions TLR10 as a potential therapeutic target in conditions where immune modulation is required, including autoimmune diseases, chronic inflammatory conditions, and certain cancers. Its regulatory function, especially in B cells, suggests TLR10 may act to fine-tune adaptive immune responses, possibly maintaining immune tolerance and preventing excessive inflammation.
In summary, while TLR10’s ligand remains unidentified, its suspected inhibitory function makes it an intriguing target for therapeutic exploration, with promising applications in autoimmune disease, chronic inflammation, infection tolerance, and cancer therapy.
toll like receptor 10 (TLR10)
Toll-like receptor 10,CD290
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con TLR10 - toll like receptor 10
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Esta página contiene 18 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | TLR10 | abx519064 | Cow Toll Like Receptor 10 (TLR10) ELISA Kit | Cow | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q6GV17 | RUO | ||
Abbexa | TLR10 | abx153341 | Human Toll Like Receptor 10 (TLR10) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 618.75 | 96 tests | RUO | |
Abbexa | TLR10 | abx493343 | Human Toll Like Receptor 10 (TLR10) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.056 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | TLR10 | abx549852 | Mouse Toll-like receptor 13 (TLR13) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q6R5N8 | RUO | ||
Abbexa | TLR10 | abx549850 | Mouse Toll-like receptor 11 (TLR11) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q6R5P0 | RUO | ||
Abbexa | TLR10 | abx549851 | Mouse Toll-like receptor 12 (TLR12) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q6QNU9 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | TLR10 | abx128824 | Toll Like Receptor 10 (TLR10) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 10 (TLR10) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q9BXR5 | RUO | |
Abbexa | TLR10 | abx145419 | Toll-Like Receptor 10 (TLR10) Antibody | Human | Polyclonal | Rabbit | Toll-Like Receptor 10 (TLR10) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | TLR10 | abx412599 | Toll-Like Receptor 10 (TLR10) Antibody | Human | Polyclonal | Rabbit | Toll-Like Receptor 10 (TLR10) | Unconjugated | WB | 462.5 | 100 µg | Q9BXR5 | RUO | |
Abbexa | TLR10 | abx320263 | Toll-Like Receptor 10 (TLR10) Antibody | Human | Polyclonal | Rabbit | Toll-Like Receptor 10 (TLR10) | Unconjugated | ELISA, IHC | 237.5 | 50 µl | Q9BXR5 | RUO | |
Abbexa | TLR10 | abx174838 | Toll Like Receptor 10 (TLR10) Antibody | Human | Monoclonal | Mouse | Toll Like Receptor 10 (TLR10) | Unconjugated | WB, IHC, IF/ICC | 750 | 1 ml | RUO | ||
Abbexa | TLR10 | abx004489 | Toll-Like Receptor 10 (TLR10) Antibody | Human | Polyclonal | Rabbit | Toll-Like Receptor 10 (TLR10) | Unconjugated | WB | 175 | 20 µl | Q9BXR5 | RUO | |
Abbexa | TLR10 | abx375310 | Toll Like Receptor 13 (TLR13) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 13 (TLR13) | Unconjugated | IHC | 337.5 | 100 µg | Q6R5N8 | RUO | |
Abbexa | TLR10 | abx326822 | Toll Like Receptor 13 (TLR13) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 13 (TLR13) | Unconjugated | ELISA, IHC | 187.5 | 50 µg | RUO | ||
Abbexa | TLR10 | abx412039 | Toll-Like Receptor 11 (TLR11) Antibody | Mouse | Polyclonal | Rabbit | Toll-Like Receptor 11 (TLR11) | Unconjugated | WB, IHC | 437.5 | 100 µg | Q6R5P0 | RUO | |
Abbexa | TLR10 | abx130298 | Toll Like Receptor 10 (TLR10) Antibody | Rat | Polyclonal | Rabbit | Toll Like Receptor 10 (TLR10) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | TLR10 | abx168288 | Human Toll Like Receptor 10 (TLR10) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | Q9BXR5 | RUO |
Abbexa | TLR10 | abx167568 | Rat Toll Like Receptor 10 (TLR10) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | C0LSK8 | RUO |
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