Family main features
Natural Cytotoxicity Triggering Receptor 3 (NCR3), also known as NKp30, is a critical receptor for natural killer (NK) cell activation and functions as part of the body’s innate immune response. NK cells are lymphocytes specialized in identifying and killing abnormal cells, such as those infected by viruses or transformed into cancer cells. Unlike T cells and B cells, which rely on antigen specificity, NK cells use a variety of activating receptors, including NCR3, to recognize stressed or infected cells. NCR3, part of the NCR family (alongside NCR1 and NCR2), plays a vital role in immune surveillance by mediating NK cell cytotoxicity and cytokine production in response to cellular stress signals. NCR3’s activation allows NK cells to promptly respond to potential threats without prior sensitization.
NCR3 is distinct among the NCRs in its broader expression across both innate and adaptive immune cells, and its activity has been shown to influence adaptive immunity. NCR3 is found not only on NK cells but also on certain subtypes of T cells and other immune cells in specific conditions, amplifying its potential for immune modulation.
The structure of NCR3 is characteristic of the immunoglobulin (Ig) superfamily, which facilitates ligand binding and signal transmission:
Extracellular Domain:
Transmembrane Domain:
Intracellular Domain:
This structural arrangement allows NCR3 to interact with both pathogen-derived and host-derived ligands, enabling it to respond flexibly to a variety of immune challenges.
NCR3 belongs to the natural cytotoxicity receptor (NCR) family, which includes NCR1 (NKp46) and NCR2 (NKp44). These receptors are part of the Ig superfamily and are known for their role in NK cell-mediated immune responses.
No significant subtypes of NCR3 have been identified; however, NCR3’s activity can vary based on the specific ligands it binds, and it is known to interact with various adaptor proteins, including CD3ζ. Additionally, alternative splicing events have been noted, which may produce isoforms with functional variations. Some of these isoforms may influence NCR3’s ligand specificity and signaling capacity, thereby impacting NK cell function in different disease settings.
NK Cell Activation and Cytotoxicity:
Recognition of Ligands:
Cytokine Secretion and Immune Modulation:
Immune Surveillance and Tumor Recognition:
Cancer Immunotherapy:
Infectious Diseases:
Autoimmune and Inflammatory Diseases:
Genetic Polymorphisms and Disease Susceptibility:
NCR3, also known as NKp30, is an activating receptor expressed primarily on NK cells, playing a crucial role in immune surveillance and immune response against tumors and infections. Structurally, NCR3 is a type I transmembrane protein, featuring an extracellular Ig-like domain, a transmembrane region that associates with CD3ζ, and a short intracellular domain. This structure allows NCR3 to bind a range of ligands, including pathogen-associated molecules, stress-induced markers like B7-H6 on tumor cells, and other ligands indicative of cellular transformation or infection.
Functionally, NCR3 mediates NK cell activation, promoting cytotoxic responses and cytokine release. By engaging ligands on stressed or infected cells, NCR3 triggers the release of cytotoxic granules and pro-inflammatory cytokines, enhancing immune responses and recruiting additional immune cells. The receptor’s involvement in immune surveillance positions it as a key target for cancer immunotherapy and antiviral strategies. In clinical applications, enhancing NCR3 activity may improve NK cell-mediated cytotoxicity in cancer and infection, while regulating its signaling could mitigate autoimmune damage.
Genetic variations in NCR3 influence disease susceptibility and individual immune responses, offering potential for personalized treatment strategies based on NCR3 genotype. Overall, NCR3’s unique structure and diverse functions underscore its significance in immune defense and its potential as a therapeutic target in immunotherapy.
natural cytotoxicity triggering receptor 3 (NCR3)
Activating natural killer receptor p30,1C7,MALS,CD337,LY117,NKp30,Natural killer cell p30-related protein
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies) relacionados con NCR3 - natural cytotoxicity triggering receptor 3
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 23 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
Contacta con nosotros en info@markelab.com, si necesitas mas informacion o alguna aclaracion. Te garantizamos respuesta en menos de 24 h.
provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | NCR3 | abx257677 | Human Activating Natural Killer Receptor P30 (NCR3) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 6.2 pg/ml | 662.5 | 96 tests | RUO | |
Abbexa | NCR3 | abx534730 | Rat Natural Cytotoxicity Triggering Receptor 3 (NCR3) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8CFD9 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | NCR3 | abx005398 | Natural Cytotoxicity Triggering Receptor 3 (NCR3) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 3 (NCR3) | Unconjugated | WB | 175 | 20 µl | O14931 | RUO | |
Abbexa | NCR3 | abx173727 | Natural Cytotoxicity Triggering Receptor 3 (NCR3) Antibody | Human | Monoclonal | Mouse | Natural Cytotoxicity Triggering Receptor 3 (NCR3) | Unconjugated | WB, IHC, IF/ICC | 775 | 1 ml | O14931 | RUO | |
Abbexa | NCR3 | abx137645 | Natural Cytotoxicity Triggering Receptor 3 (NCR3) Antibody | Human | Monoclonal | Mouse | Natural Cytotoxicity Triggering Receptor 3 (NCR3) | 225 | 5 µg | RUO | ||||
Abbexa | NCR3 | abx336716 | Natural Cytotoxicity Triggering Receptor 3 (NCR3) Antibody (FITC) | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 3 (NCR3) | FITC | 162.5 | 20 µg | O14931 | RUO | ||
Abbexa | NCR3 | abx210873 | Natural Cytotoxicity Triggering Receptor 3 (NCR3) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 3 (NCR3) | Unconjugated | ELISA, IHC | 250 | 50 µl | O14931 | RUO | |
Abbexa | NCR3 | abx336717 | Natural Cytotoxicity Triggering Receptor 3 (NCR3) Antibody (Biotin) | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 3 (NCR3) | Biotin | ELISA | 162.5 | 20 µg | O14931 | RUO | |
Abbexa | NCR3 | abx334059 | Natural Cytotoxicity Triggering Receptor 3 (NCR3) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 3 (NCR3) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | O14931 | RUO | |
Abbexa | NCR3 | abx137429 | Natural Cytotoxicity Triggering Receptor 3 (NCR3) Antibody | Human | Monoclonal | Mouse | Natural Cytotoxicity Triggering Receptor 3 (NCR3) | Unconjugated | 225 | 5 µg | RUO | |||
Abbexa | NCR3 | abx130836 | Natural Cytotoxicity Triggering Receptor 3 (NCR3) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 3 (NCR3) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | O14931 | RUO | |
Abbexa | NCR3 | abx270072 | Natural Cytotoxicity Triggering Receptor 3 (NCR3) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 3 (NCR3) | Unconjugated | FCM | 275 | 50 tests | RUO | ||
Abbexa | NCR3 | abx336715 | Natural Cytotoxicity Triggering Receptor 3 (NCR3) Antibody (HRP) | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 3 (NCR3) | HRP | ELISA | 162.5 | 20 µg | O14931 | RUO | |
Abbexa | NCR3 | abx210874 | Natural Cytotoxicity Triggering Receptor 3 (NCR3) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 3 (NCR3) | Unconjugated | ELISA, IHC | 250 | 50 µl | O14931 | RUO | |
Abbexa | NCR3 | abx330156 | Natural Cytotoxicity Triggering Receptor 3 (NCR3) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 3 (NCR3) | Unconjugated | ELISA, WB | 187.5 | 50 µg | O14931 | RUO | |
Abbexa | NCR3 | abx119002 | Natural Cytotoxicity Triggering Receptor 3 (NCR3) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 3 (NCR3) | Unconjugated | WB | 43.75 | 10 µg | O14931 | RUO | |
Abbexa | NCR3 | abx330127 | Natural Cytotoxicity Triggering Receptor 3 (NCR3) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 3 (NCR3) | Unconjugated | ELISA, WB | 187.5 | 50 µg | O14931 | RUO | |
Abbexa | NCR3 | abx130835 | Natural Cytotoxicity Triggering Receptor 3 (NCR3) Antibody | Rat | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 3 (NCR3) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | NCR3 | abx690099 | Human Natural Cytotoxicity Triggering Receptor 3 (NCR3) Protein | Human | Recombinant | Human | SDS-PAGE | 250 | 10 µg | O14931 | RUO | |
Abbexa | NCR3 | abx261277 | Natural Cytotoxicity Triggering Receptor 3 (NCR3) Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 5 µg | O14931 | RUO | ||
Abbexa | NCR3 | abx168770 | Rat Natural Cytotoxicity Triggering Receptor 3 (NCR3) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | Q8CFD9 | RUO |
Abbexa | NCR3 | abx694224 | Human Natural Cytotoxicity Triggering Receptor 3 (NCR3) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 300 | 20 µg | O14931 | RUO | |
Abbexa | NCR3 | abx168769 | Human Natural Cytotoxicity Triggering Receptor 3 (NCR3) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | O14931 | RUO |
Te recomendamos que si no encuentras lo que buscas, utilices el buscador, refinando la búsqueda según tu criterio y usando Alias, o bien contacta con nosotros.