Human Natural Cytotoxicity Triggering Receptor 3 (NCR3) Protein
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935106861
info@markelab.com
Precio
208€ (10 µg)
Protein NCR3
proveedor
Abbexareference
abx168769Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human NCR3 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
Natural Cytotoxicity Triggering Receptor 3 (NCR3), also known as NKp30, is a critical receptor for natural killer (NK) cell activation and functions as part of the body’s innate immune response. NK cells are lymphocytes specialized in identifying and killing abnormal cells, such as those infected by viruses or transformed into cancer cells. Unlike T cells and B cells, which rely on antigen specificity, NK cells use a variety of activating receptors, including NCR3, to recognize stressed or infected cells. NCR3, part of the NCR family (alongside NCR1 and NCR2), plays a vital role in immune surveillance by mediating NK cell cytotoxicity and cytokine production in response to cellular stress signals. NCR3’s activation allows NK cells to promptly respond to potential threats without prior sensitization. NCR3 is distinct among the NCRs in its broader expression across both innate and adaptive immune cells, and its activity has been shown to influence adaptive immunity. NCR3 is found not only on NK cells but also on certain subtypes of T cells and other immune cells in specific conditions, amplifying its potential for immune modulation.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Natural Cytotoxicity Triggering Receptor 3 (NCR3)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 16.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser22-Gly135 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
NCR3
dry ice
No
availability
Shipped within 5-7 working days.
alias
Activating natural killer receptor p30,1C7,MALS,CD337,LY117,NKp30,Natural killer cell p30-related protein
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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