Family main features
Natural Cytotoxicity Triggering Receptor 2 (NCR2), also known as NKp44, is an activating receptor on the surface of natural killer (NK) cells. NK cells are crucial components of the innate immune system, specializing in the recognition and destruction of abnormal cells, including tumor cells and virus-infected cells. Unlike other immune cells, such as T and B lymphocytes, which rely on antigen-specific receptors, NK cells use NCR2 and other activating receptors to identify stressed, infected, or transformed cells without prior sensitization. This unique ability enables NK cells to mount a rapid immune response.
NCR2 is part of the NCR family, which also includes NCR1 (NKp46) and NCR3 (NKp30). These receptors, along with others like NKG2D, enable NK cells to recognize target cells that exhibit ligands associated with cellular stress or infection. NCR2 is specifically expressed on activated NK cells and is involved in both direct cytotoxicity and the secretion of cytokines and chemokines, amplifying the immune response. NCR2 plays an essential role in immune surveillance, contributing to the early detection and elimination of tumors and infection.
NCR2 is a type I transmembrane protein that belongs to the immunoglobulin (Ig) superfamily, with a structural composition tailored for ligand binding and signal transduction. Its key structural features include:
Extracellular Domain:
Transmembrane Domain:
Intracellular Domain:
The structure of NCR2 enables it to interact with a diverse range of ligands, including viral proteins, tumor-associated antigens, and other stress-induced ligands, positioning it as an important component of NK cell-mediated immune responses.
NCR2, classified under the natural cytotoxicity receptor (NCR) family, is one of the main activating receptors expressed on NK cells, along with NCR1 and NCR3. Each of these receptors plays a distinct role in recognizing various types of abnormal cells. Unlike NCR1, which is constitutively expressed on resting NK cells, NCR2 expression is induced upon NK cell activation, and it is predominantly expressed in peripheral blood NK cells and activated NK cells.
No major subtypes of NCR2 have been identified. However, some genetic polymorphisms and alternative splicing variants may influence the receptor's expression level, ligand-binding affinity, and downstream signaling efficiency. These genetic differences could impact individual immune responses, particularly in cancer and viral infections.
NK Cell Activation and Cytotoxicity:
Recognition of Pathogen-Derived and Stress-Induced Ligands:
Immune Modulation and Cytokine Secretion:
Cancer Immunotherapy:
Infectious Diseases:
Autoimmunity and Inflammatory Disorders:
Genetic Polymorphisms and Disease Susceptibility:
NCR2, also known as NKp44, is an activating receptor on NK cells that plays a critical role in immune surveillance and the body’s defense against tumors and pathogens. Structurally, NCR2 is a type I transmembrane protein with an Ig-like extracellular domain, a transmembrane region that binds the DAP12 adaptor, and a short intracellular tail. This structure enables NCR2 to recognize a diverse range of ligands on the surface of abnormal cells, initiating NK cell cytotoxicity and cytokine release.
Functionally, NCR2 mediates NK cell activation, enhancing immune responses through direct cytotoxicity and cytokine production. It binds to viral and bacterial ligands as well as stress-induced ligands on transformed cells, contributing to early detection and elimination of infected or malignant cells. The receptor's activation also amplifies immune responses, recruiting additional immune cells and enhancing inflammation in response to tumors and infections.
Clinically, NCR2 has significant therapeutic potential in cancer immunotherapy, infectious diseases, and autoimmune disorders. Enhancing NCR2 signaling could improve NK cell-mediated cancer cell killing, while modulating its activity might prevent autoimmune damage. Genetic variations in NCR2 also influence individual immune responses, offering potential for personalized therapies based on NCR2 gene profiling. As research continues, NCR2 remains a promising target in immunotherapy and immune regulation for various diseases.
natural cytotoxicity triggering receptor 2 (NCR2)
Lymphocyte antigen 95 homolog,LY95,CD336,NKP44,NK-p44,NK cell-activating receptor,Natural killer cell p44-related protein
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Esta página contiene 15 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | NCR2 | EH4293 | Human NKp44/NCR2(Natural cytotoxicity triggering receptor 2) ELISA Kit | human | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 31.25-2000pg/ml | 96T | O95944 | RUO | ||
Abbexa | NCR2 | abx257676 | Human Natural Cytotoxicity Triggering Receptor 2 (NCR2) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | O95944 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | NCR2 | FNab01468 | anti- CD336 antibody | human | polyclonal | Rabbit | natural cytotoxicity triggering receptor 2 | IgG | Unconjugated | ELISA, WB | 100µg | O95944 | RUO | |
Abbexa | NCR2 | abx231468 | Natural Cytotoxicity Triggering Receptor 2 (NCR2) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 2 (NCR2) | Unconjugated | ELISA, WB | 350 | 100 µg | O95944 | RUO | |
Abbexa | NCR2 | abx322054 | Natural Cytotoxicity Triggering Receptor 2 (NCR2) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 2 (NCR2) | Unconjugated | ELISA | 250 | 50 µl | O95944 | RUO | |
Abbexa | NCR2 | abx123227 | Natural Cytotoxicity Triggering Receptor 2 (NCR2) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 2 (NCR2) | Unconjugated | WB | 175 | 20 µl | O95944 | RUO | |
Abbexa | NCR2 | abx137736 | Natural Cytotoxicity Triggering Receptor 2 (NCR2) Antibody | Human | Monoclonal | Mouse | Natural Cytotoxicity Triggering Receptor 2 (NCR2) | 225 | 5 µg | RUO | ||||
Abbexa | NCR2 | abx339913 | Natural Cytotoxicity Triggering Receptor 2 (NCR2) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 2 (NCR2) | Unconjugated | ELISA, IHC | 250 | 50 µl | O95944 | RUO | |
Abbexa | NCR2 | abx323755 | Natural Cytotoxicity Triggering Receptor 2 (NCR2) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 2 (NCR2) | Unconjugated | ELISA, WB | 187.5 | 50 µg | O95944 | RUO | |
Abbexa | NCR2 | abx130834 | Natural Cytotoxicity Triggering Receptor 2 (NCR2) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 2 (NCR2) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO | ||
Abbexa | NCR2 | abx339914 | Natural Cytotoxicity Triggering Receptor 2 (NCR2) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 2 (NCR2) | Unconjugated | ELISA, IHC | 250 | 50 µl | O95944 | RUO | |
Abbexa | NCR2 | abx114027 | Natural Cytotoxicity Triggering Receptor 2 (NCR2) Antibody | Human | Polyclonal | Rabbit | Natural Cytotoxicity Triggering Receptor 2 (NCR2) | Unconjugated | ELISA, WB | 612.5 | 100 µl | O95944 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | NCR2 | abx261242 | Natural Cytotoxicity Triggering Receptor 2 (NCR2) Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 5 µg | O95944 | RUO | ||
Abbexa | NCR2 | abx168768 | Human Natural Cytotoxicity Triggering Receptor 2 (NCR2) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 187.5 | 10 µg | O95944 | RUO |
Abbexa | NCR2 | abx694097 | Human Natural Cytotoxicity Triggering Receptor 2 (NCR2) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 462.5 | 20 µg | O95944 | RUO |
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