Human Natural Cytotoxicity Triggering Receptor 2 (NCR2) Protein
481€ (20 µg)
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name
Human Natural Cytotoxicity Triggering Receptor 2 (NCR2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx694097
tested applications
SDS-PAGE
Description
Human Natural Cytotoxicity Triggering Receptor 2 (NCR2) Protein is a recombinant Human protein expressed in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: Calculated MW: 20 kDa Observed MW (SDS-PAGE): 37 kDa Sequence Fragment: Met1-Pro190 Tag: C-terminal His tag |
| Expression | Recombinant |
| Purity | >88% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Form | Lyophilized Reconstitute in sterile H2O. Do not vortex. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store lyophilized between -20 °C and -80 °C. |
| Dry Ice | No |
| UniProt ID | O95944 |
| Alias | Lymphocyte antigen 95 homolog,LY95,CD336,NKP44,NK-p44,NK cell-activating receptor,Natural killer cell p44-related protein |
| Background | Protein NCR2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Natural Cytotoxicity Triggering Receptor 2 (NCR2), also known as NKp44, is an activating receptor on the surface of natural killer (NK) cells. NK cells are crucial components of the innate immune system, specializing in the recognition and destruction of abnormal cells, including tumor cells and virus-infected cells. Unlike other immune cells, such as T and B lymphocytes, which rely on antigen-specific receptors, NK cells use NCR2 and other activating receptors to identify stressed, infected, or transformed cells without prior sensitization. This unique ability enables NK cells to mount a rapid immune response. NCR2 is part of the NCR family, which also includes NCR1 (NKp46) and NCR3 (NKp30). These receptors, along with others like NKG2D, enable NK cells to recognize target cells that exhibit ligands associated with cellular stress or infection. NCR2 is specifically expressed on activated NK cells and is involved in both direct cytotoxicity and the secretion of cytokines and chemokines, amplifying the immune response. NCR2 plays an essential role in immune surveillance, contributing to the early detection and elimination of tumors and infection.
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