Family main features
CLEC12A (C-type lectin domain family 12 member A) is a member of the C-type lectin receptor (CLR) family, a group of proteins characterized by their ability to recognize carbohydrate structures on the surface of pathogens or host cells. As a receptor with immunoregulatory functions, CLEC12A plays a critical role in the immune system, particularly in the context of myeloid cell biology. Its primary expression is found on a variety of immune cells, especially those within the myeloid lineage, including monocytes, macrophages, and dendritic cells. CLEC12A is involved in modulating immune responses to pathogens and tumors, playing a role in both the innate immune system and in the cross-talk between innate and adaptive immunity.
CLEC12A has garnered attention due to its involvement in inflammation and its potential therapeutic implications in diseases involving immune dysregulation, such as cancer and autoimmune disorders. Understanding its functions, structure, and signaling pathways is critical for determining its role in immune responses and for developing therapeutic strategies to target CLEC12A in various clinical contexts.
The protein structure of CLEC12A is typical of C-type lectin receptors but has unique features that define its function:
Extracellular C-Type Lectin Domain (CTLD):
Transmembrane Region:
Intracellular Signaling Motif:
Splice Variants:
CLEC12A belongs to the C-type lectin domain family 12, which is a subclass within the broader family of C-type lectin receptors. This family consists of a diverse group of receptors that are primarily expressed on immune cells and involved in pathogen recognition, antigen presentation, and regulation of immune responses. CLEC12A is closely related to other CLRs such as Dectin-1 (CLEC7A) and Dectin-2 (CLEC6A), which also participate in innate immune responses to fungal and bacterial infections. However, CLEC12A is distinct in its expression and its role in immune suppression and regulation.
CLEC12A does not have subtypes per se, but it may be differentially expressed in various cell types or tissue environments. It is expressed predominantly in myeloid cells, including monocytes, dendritic cells, and macrophages, which are critical for initiating immune responses. Its expression levels can vary depending on the state of the immune system, such as in inflammation or infection.
Immune Regulation and Inhibition:
Modulation of Myeloid Cell Function:
Role in Pathogen Recognition:
Cross-Talk with Other Immune Receptors:
Cancer Immunotherapy:
Autoimmune Diseases:
Infectious Diseases:
CLEC12A is a C-type lectin receptor expressed predominantly on myeloid cells, including dendritic cells, macrophages, and monocytes. It plays a crucial role in immune regulation by acting as an inhibitory receptor, primarily through its intracellular ITIM domain. This function is essential in maintaining immune homeostasis and preventing excessive inflammation, which could lead to autoimmune diseases or chronic inflammatory conditions.
The receptor is involved in recognizing DAMPs, which are signals of tissue damage or necrosis, thereby linking innate and adaptive immune responses. While the exact ligands for CLEC12A remain partially undefined, it is clear that it contributes to pathogen recognition, antigen presentation, and the modulation of immune cell function. CLEC12A’s inhibitory role is significant in controlling immune responses to infection and inflammation, but it also positions CLEC12A as a target in cancer immunotherapy, where enhancing immune activation may be beneficial.
Clinically, CLEC12A's involvement in cancer, autoimmune diseases, and infectious diseases highlights its potential as a therapeutic target. Future studies focusing on its ligand recognition, signaling mechanisms, and role in disease progression will provide deeper insights into its full range of biological functions and clinical applications.
C-type lectin domain family 12 member A (CLEC12A)
CLL1,MICL,CD371,CLL-1,DCAL-2,C-type lectin-like molecule 1,Myeloid inhibitory C-type lectin-like receptor,Dendritic cell-associated lectin 2
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (ELISA Kits, Primary Antibodies) relacionados con CLEC12A - C-type lectin domain family 12 member A
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Esta página contiene 7 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CLEC12A | abx384743 | Human C-Type Lectin Domain Family 12 Member A (CLEC12A) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | Q5QGZ9 | RUO |
Abbexa | CLEC12A | abx388939 | Mouse C-Type Lectin Domain Family 12 Member A (CLEC12A) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 46.9 pg/ml | 687.5 | 96 tests | Q504P2 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CLEC12A | abx320146 | C-Type Lectin Domain Family 12 Member A (CLEC12A) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 12 Member A (CLEC12A) | Unconjugated | ELISA, IHC | 237.5 | 50 µl | Q5QGZ9 | RUO | |
Abbexa | CLEC12A | abx430797 | C-Type Lectin Domain Family 12 Member A (CLEC12A) Antibody | Human | Polyclonal | Goat | C-Type Lectin Domain Family 12 Member A (CLEC12A) | Unconjugated | P-ELISA, WB | 387.5 | 200 µl | RUO | ||
Abbexa | CLEC12A | abx025571 | C-Type Lectin Domain Family 12 Member A (CLEC12A) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 12 Member A (CLEC12A) | Unconjugated | ELISA, WB | 250 | 80 µl | Q5QGZ9 | RUO | |
Abbexa | CLEC12A | abx322232 | C-Type Lectin Domain Family 12 Member A (CLEC12A) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 12 Member A (CLEC12A) | Unconjugated | ELISA, WB, IHC | 237.5 | 50 µl | Q5QGZ9 | RUO | |
Abbexa | CLEC12A | abx004772 | C-Type Lectin Domain Family 12 Member A (CLEC12A) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 12 Member A (CLEC12A) | Unconjugated | WB | 175 | 20 µl | Q5QGZ9 | RUO |
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