C-Type Lectin Domain Family 12 Member A (CLEC12A) Antibody
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Description
CLEC12A Antibody is a Rabbit Polyclonal against CLEC12A.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | C-Type Lectin Domain Family 12 Member A (CLEC12A) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q5QGZ9 |
| Gene ID | 160364 |
| NCBI Accession | NP_001193939.1, NM_001207010.1 |
| OMIM | 612088 |
| Alias | CLL1,MICL,CD371,CLL-1,DCAL-2,C-type lectin-like molecule 1,Myeloid inhibitory C-type lectin-like receptor,Dendritic cell-associated lectin 2 |
| Background | Antibody anti-CLEC12A |
| Status | RUO |
Descripción
CLEC12A (C-type lectin domain family 12 member A) is a member of the C-type lectin receptor (CLR) family, a group of proteins characterized by their ability to recognize carbohydrate structures on the surface of pathogens or host cells. As a receptor with immunoregulatory functions, CLEC12A plays a critical role in the immune system, particularly in the context of myeloid cell biology. Its primary expression is found on a variety of immune cells, especially those within the myeloid lineage, including monocytes, macrophages, and dendritic cells. CLEC12A is involved in modulating immune responses to pathogens and tumors, playing a role in both the innate immune system and in the cross-talk between innate and adaptive immunity.CLEC12A has garnered attention due to its involvement in inflammation and its potential therapeutic implications in diseases involving immune dysregulation, such as cancer and autoimmune disorders. Understanding its functions, structure, and signaling pathways is critical for determining its role in immune responses and for developing therapeutic strategies to target CLEC12A in various clinical contexts.
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