BSG - basigin | Elisa - Clia - Antibody - Protein

Family main features

Background

Basigin, also known as CD147 or EMMPRIN (extracellular matrix metalloproteinase inducer), is a transmembrane glycoprotein that is widely expressed in various tissues and cell types. It is part of the immunoglobulin superfamily and plays a significant role in several physiological and pathological processes, including embryonic development, neural function, inflammation, and cancer progression. Basigin is known for its involvement in the induction of matrix metalloproteinases (MMPs), which are enzymes that degrade the extracellular matrix, thus facilitating tissue remodeling and tumor invasion.


Protein Structure

Basigin is composed of a single polypeptide chain with two immunoglobulin-like domains in its extracellular region. The protein has a transmembrane domain that anchors it to the cell membrane and a short cytoplasmic tail. The extracellular region is heavily glycosylated, which is crucial for its interactions with other proteins and its function in cell adhesion and signaling.


Classification and Subtypes

Basigin belongs to the immunoglobulin superfamily and is classified under the subclass of cell adhesion molecules (CAMs). There are several isoforms of Basigin, which arise from alternative splicing. These isoforms vary mainly in the length of their extracellular domain, which can influence their functional interactions and tissue-specific expression patterns.


Function and Biological Significance

Basigin is involved in numerous biological processes:


  • Induction of MMPs: It stimulates the production of matrix metalloproteinases, facilitating extracellular matrix remodeling and promoting cancer cell invasion and metastasis.
  • Cell Adhesion: Basigin mediates cell-cell and cell-matrix interactions, contributing to tissue organization and repair.
  • Transport of Metabolites: It plays a role in the transport of lactate and other metabolites across the cell membrane, which is particularly important in tissues with high metabolic activity.
  • Immune Response: Basigin is involved in the regulation of immune cell functions, including lymphocyte activation and trafficking.


Clinical Issues

Basigin has been implicated in various clinical conditions:


  • Cancer: Overexpression of Basigin is associated with poor prognosis in several types of cancer, including breast, prostate, and colorectal cancers. It is involved in tumor growth, angiogenesis, and metastasis.
  • Infectious Diseases: Basigin acts as a receptor for certain pathogens, including the malaria parasite Plasmodium falciparum, facilitating their entry into host cells.
  • Cardiovascular Diseases: Basigin is implicated in the development of atherosclerosis and myocardial ischemia due to its role in inflammatory processes and tissue remodeling.


Summary

Basigin is a multifunctional protein that plays crucial roles in cell adhesion, metabolism, and immune response. Its involvement in the induction of MMPs makes it a key player in tissue remodeling and cancer progression. The overexpression of Basigin in various cancers and its role as a receptor for pathogens highlight its clinical significance. Understanding the molecular mechanisms of Basigin's functions and its interactions with other proteins may provide insights into potential therapeutic targets for treating cancer and other diseases.


BSG Recommended name:

Basigin (BSG)

Aliases for BSG

OK,5F7,TCSF,CD147,EMPRIN,HAb18G,EMMPRIN,Leukocyte activation antigen M6,Extracellular matrix metalloproteinase inducer,Ok blood group,Tumor cell-derived collagenase stimulatory factor

En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con BSG - basigin

Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.

Esta página contiene 75 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda

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immunoassays

providerCodereferencenamereactivitysample typeassay typetest rangesensitivitypricesize 1uniprot idstatus
AbbexaBSGabx518610Chicken Basigin (BSG) ELISA KitChickenTissue homogenates,Cell lysates,Other biological fluids0.156 ng/ml - 10 ng/ml687.596 testsP17790RUO
AbbexaBSGabx518609Cow Basigin (BSG) ELISA KitCowTissue homogenates,Cell lysates,Other biological fluids0.156 ng/ml - 10 ng/ml687.596 testsQ865R3RUO
FineTestBSGEH0073Human CD147(Extracellular Matrix Metalloproteinase Inducer) ELISA KithumanSerum,Plasma,Tissue homogenates,Other biological fluidsSandwich ELISA, Double Antibody15.625-1000pg/ml96TP35613RUO
AbbexaBSGabx250211Human Basigin (BSG) ELISA KitHumanTissue homogenates,Cell lysates,Other biological fluidsSandwich15.6 pg/ml - 1000 pg/ml9.38 pg/ml52596 testsP35613RUO
AbbexaBSGabx151402Human Basigin (BSG) ELISA KitHumanSerum,Plasma,Tissue homogenates,Cell lysates,Other biological fluidsSandwich31.2 pg/ml - 2000 pg/ml< 11.8 pg/ml662.596 testsP35613RUO
AbbexaBSGabx492852Human Basigin (BSG) CLIA KitHumanSerum, plasma, tissue homogenates, cell lysates and other biological fluids.Sandwich31.25 pg/ml - 2000 pg/ml< 12.7 pg/ml84596 testsRUO
AbbexaBSGabx196642Human Basigin (BSG) CLIA KitHumanSerum, plasma and other biological fluids.Sandwich12.5 pg/ml - 800 pg/ml7.5 pg/ml643.596 testsRUO
AbbexaBSGabx595744Basigin (BSG) Cell ELISA KitHumanCell ELISA493.7596 testsP35613RUO
AbbexaBSGabx518612Mouse Basigin (BSG) ELISA KitMouseSerum,Plasma,Tissue homogenates,Cell lysates,Other biological fluidsSandwich78 pg/ml - 5000 pg/ml537.596 testsP18572RUO
AbbexaBSGabx362549Rabbit Basigin (BSG) ELISA KitRabbitSerum,Plasma,Other biological fluidsSandwich0.625 pg/ml - 40 pg/ml0.38 pg/ml662.596 testsRUO
FineTestBSGER0603Rat Bsg(Basigin) ELISA KitratSerum,Plasma,Tissue homogenates,Other biological fluidsSandwich ELISA, Double Antibody78.125-5000pg/ml96TP26453RUO
AbbexaBSGabx492853Rat Basigin (BSG) CLIA KitRatSerum, plasma, lung lavage fluid and other biological fluids.Sandwich15.62 pg/ml - 1000 pg/ml< 5.5 pg/ml84596 testsRUO
AbbexaBSGabx155469Rat Basigin (BSG) ELISA KitRatSerum,Plasma,Other biological fluidsSandwich15.62 pg/ml - 1000 pg/ml< 5.5 pg/ml618.7596 testsRUO

Primary Antibodies

providerCodereferencenamereactivityclonalityhostimmunogen targetisotypeconjugationtested applicationspricesize 1uniprot idstatus
FineTestBSGFNab01430anti- CD147 antibodyhumanpolyclonalRabbitbasigin (Ok blood group)IgGUnconjugatedELISA, WB, IHC100µgP35613RUO
AbbexaBSGabx139071Basigin (BSG) AntibodyHumanMonoclonalMouseBasigin (BSG)UnconjugatedWB, FCM, FUNC287.50.1 mgP35613RUO
AbbexaBSGabx210768Basigin (BSG) AntibodyHumanPolyclonalRabbitBasigin (BSG)UnconjugatedELISA, IHC25050 µlP35613RUO
AbbexaBSGabx228530Basigin (BSG) Antibody (Biotin)HumanMonoclonalMouseBasigin (BSG)IgG1 BiotinFCM106.2525 µgP35613RUO
AbbexaBSGabx172313Basigin (BSG) AntibodyHumanMonoclonalMouseBasigin (BSG)UnconjugatedWB, IHC, IF/ICC275100 µlRUO
AbbexaBSGabx228538Basigin (BSG) Antibody (PerCP / Cyanine 5.5)HumanMonoclonalMouseBasigin (BSG)IgG1 PerCP / Cyanine 5.5FCM112.520 testsP35613RUO
AbbexaBSGabx211214Basigin (BSG) AntibodyHumanPolyclonalRabbitBasigin (BSG)UnconjugatedELISA, WB, IHC25050 µlP35613RUO
AbbexaBSGabx111188Basigin (BSG) AntibodyHumanPolyclonalRabbitBasigin (BSG)UnconjugatedELISA, WB, IHC612.5100 µlP35613RUO
AbbexaBSGabx139070Basigin (BSG) AntibodyHumanMonoclonalMouseBasigin (BSG)UnconjugatedWB, IHC-P, FCM, IP287.50.1 mgP35613RUO
AbbexaBSGabx270276Basigin (BSG) AntibodyHumanPolyclonalRabbitBasigin (BSG)UnconjugatedFCM27550 testsRUO
AbbexaBSGabx323700Basigin (BSG) AntibodyHumanPolyclonalRabbitBasigin (BSG)UnconjugatedELISA, WB187.550 µgP35613RUO
AbbexaBSGabx349856Basigin (BSG) AntibodyHumanMonoclonalMouseBasigin (BSG)UnconjugatedELISA, WB, IHC, IF/ICC, FCM287.550 µlP35613RUO
AbbexaBSGabx228531Basigin (BSG) Antibody (FITC)HumanMonoclonalMouseBasigin (BSG)IgG1 FITCFCM93.7520 testsP35613RUO
AbbexaBSGabx108011Basigin (BSG) Antibody (HRP)HumanPolyclonalRabbitBasigin (BSG)HRPELISA162.520 µgP35613RUO
AbbexaBSGabx228535Basigin (BSG) Antibody (PE / Cyanine 5)HumanMonoclonalMouseBasigin (BSG)IgG1 PE / Cyanine 5FCM12520 testsP35613RUO
AbbexaBSGabx139072Basigin (BSG) Antibody (PE)HumanMonoclonalMouseBasigin (BSG)PEFCM400100 testsP35613RUO
AbbexaBSGabx036309Basigin (BSG) AntibodyHumanPolyclonalRabbitBasigin (BSG)UnconjugatedELISA, WB337.5100 µgRUO
AbbexaBSGabx109565Basigin (BSG) AntibodyHumanPolyclonalRabbitBasigin (BSG)UnconjugatedELISA, WB, IHC162.520 µgP35613RUO
AbbexaBSGabx378016Extracellular Matrix Metalloproteinase Inducer (EMMPRIN/CD147) Antibody PairHumanExtracellular Matrix Metalloproteinase Inducer (EMMPRIN/CD147)ELISA5255 × 96 testsP35613RUO
AbbexaBSGabx228536Basigin (BSG) Antibody (PE / Cyanine 7)HumanMonoclonalMouseBasigin (BSG)IgG1 PE / Cyanine 7FCM112.520 testsP35613RUO
AbbexaBSGabx413468Basigin (BSG) Antibody (PE)HumanMonoclonalMouseBasigin (BSG)PEFCM487.5100 testsP35613RUO
AbbexaBSGabx414662Basigin (BSG) AntibodyHumanMonoclonalMouseBasigin (BSG)UnconjugatedWB, FCM650100 µgP35613RUO
AbbexaBSGabx376531Basigin (BSG) AntibodyHumanPolyclonalRabbitBasigin (BSG)IgG UnconjugatedWB, IHC, IF/ICC243.7550 µgRUO
AbbexaBSGabx413470Basigin (BSG) AntibodyHumanMonoclonalMouseBasigin (BSG)UnconjugatedWB, FCM, IP737.51 mgP35613RUO
AbbexaBSGabx228539Basigin (BSG) Antibody (AF488)HumanMonoclonalMouseBasigin (BSG)IgG1 AF488FCM112.520 testsP35613RUO
AbbexaBSGabx228540Basigin (BSG) Antibody (AF647)HumanMonoclonalMouseBasigin (BSG)IgG1 AF647FCM112.520 testsP35613RUO
AbbexaBSGabx128944Basigin (BSG) AntibodyHumanPolyclonalRabbitBasigin (BSG)UnconjugatedWB, IHC, IF/ICC262.5100 µlP35613RUO
AbbexaBSGabx029315Basigin (BSG) AntibodyHumanPolyclonalRabbitBasigin (BSG)UnconjugatedELISA, WB281.2580 µlP35613RUO
AbbexaBSGabx228529Basigin (BSG) AntibodyHumanMonoclonalMouseBasigin (BSG)IgG1 UnconjugatedIHC, FCM7525 µgP35613RUO
AbbexaBSGabx139074Basigin (BSG) Antibody (Biotin)HumanMonoclonalMouseBasigin (BSG)BiotinWB, IHC-P, FCM, IP3500.1 mgP35613RUO
AbbexaBSGabx106594Basigin (BSG) Antibody (FITC)HumanPolyclonalRabbitBasigin (BSG)FITC162.520 µgP35613RUO
AbbexaBSGabx139075Basigin (BSG) Antibody (FITC)HumanMonoclonalMouseBasigin (BSG)FITCFCM350100 testsP35613RUO
AbbexaBSGabx228532Basigin (BSG) Antibody (PE)HumanMonoclonalMouseBasigin (BSG)IgG1 PEFCM112.520 testsP35613RUO
AbbexaBSGabx413467Basigin (BSG) Antibody (APC)HumanMonoclonalMouseBasigin (BSG)APCFCM487.5100 testsP35613RUO
AbbexaBSGabx413466Basigin (BSG) AntibodyHumanMonoclonalMouseBasigin (BSG)UnconjugatedWB, FCM, IP462.5200 µgP35613RUO
AbbexaBSGabx139073Basigin (BSG) Antibody (APC)HumanMonoclonalMouseBasigin (BSG)APCFCM400100 testsP35613RUO
AbbexaBSGabx228533Basigin (BSG) Antibody (APC)HumanMonoclonalMouseBasigin (BSG)IgG1 APCFCM112.520 testsP35613RUO
AbbexaBSGabx105177Basigin (BSG) Antibody (Biotin)HumanPolyclonalRabbitBasigin (BSG)BiotinELISA162.520 µgP35613RUO
AbbexaBSGabx231430Basigin (BSG) AntibodyHumanPolyclonalRabbitBasigin (BSG)UnconjugatedELISA, WB, IHC350100 µgP35613RUO
AbbexaBSGabx328343Basigin (BSG) AntibodyHumanPolyclonalRabbitBasigin (BSG)UnconjugatedELISA, WB, IHC187.550 µgP35613RUO
AbbexaBSGabx013476Basigin (BSG) AntibodyHumanPolyclonalRabbitBasigin (BSG)UnconjugatedWB, IHC43.7510 µgP35613RUO
AbbexaBSGabx001317Basigin (BSG) AntibodyHumanPolyclonalRabbitBasigin (BSG)UnconjugatedWB, IHC, IP17520 µlP35613RUO
AbbexaBSGabx139069Basigin (BSG) AntibodyHumanMonoclonalMouseBasigin (BSG)UnconjugatedIHC-P, FCM287.50.1 mgP35613RUO
AbbexaBSGabx413959Basigin (BSG) AntibodyMouseMonoclonalRatBasigin (BSG)UnconjugatedWB, IHC, FCM462.5250 µgP18572RUO
AbbexaBSGabx413960Basigin (BSG) AntibodyMouseMonoclonalRatBasigin (BSG)UnconjugatedWB, IHC, FCM337.5100 µgP18572RUO
AbbexaBSGabx104498Basigin (BSG) AntibodyMousePolyclonalRabbitBasigin (BSG)UnconjugatedWB, IHC, IF/ICC262.5100 µlRUO
AbbexaBSGabx019020Basigin (BSG) AntibodyMousePolyclonalRabbitBasigin (BSG)UnconjugatedWB300100 µgP18572RUO
AbbexaBSGabx172314Basigin (BSG) AntibodyRatMonoclonalMouseBasigin (BSG)UnconjugatedWB, IHC, IF/ICC812.51 mlRUO
AbbexaBSGabx270519Basigin (BSG) Antibody (FITC)RatPolyclonalRabbitBasigin (BSG)FITCFCM575200 testsRUO
AbbexaBSGabx270983Basigin (BSG) Antibody (PE)RatPolyclonalRabbitBasigin (BSG)PEFCM687.5200 testsRUO
AbbexaBSGabx415448Basigin (BSG) Antibody (PE)RatMonoclonalMouseBasigin (BSG)PEFCM512.5100 testsP26453RUO
AbbexaBSGabx270221Basigin (BSG) AntibodyRatPolyclonalRabbitBasigin (BSG)UnconjugatedFCM30050 testsRUO
AbbexaBSGabx130369Basigin (BSG) AntibodyRatPolyclonalRabbitBasigin (BSG)UnconjugatedWB, IHC, IF/ICC275100 µlP26453RUO
AbbexaBSGabx270751Basigin (BSG) Antibody (APC)RatPolyclonalRabbitBasigin (BSG)APCFCM800200 testsRUO
AbbexaBSGabx415447Basigin (BSG) Antibody (FITC)RatMonoclonalMouseBasigin (BSG)FITCFCM425100 µgP26453RUO

Proteins and Peptides

providerCodereferencenameoriginexpressionhostconjugationtested applicationspricesize 1uniprot idstatus
AbbexaBSGabx167641Rat Basigin (BSG) ProteinRatRecombinantE. coliUnconjugatedWB, SDS-PAGE22510 µgP26453RUO
FineTestBSGP2750Recombinant Human EMMPRINHumanRecombinantHEK 293 cellsWestern Blot, ELISA50μgQ54A51RUO
AbbexaBSGabx680032Human Basigin (BSG) ProteinHumanRecombinantInsectUnconjugatedSDS-PAGE2252 µgRUO
AbbexaBSGabx166672Human Basigin (BSG) ProteinHumanRecombinantE. coliUnconjugatedWB, SDS-PAGE212.510 µgRUO
AbbexaBSGabx691611Mouse Basigin (BSG) ProteinMouseRecombinantHEK293 cellsSDS-PAGE837.5100 µgP18572RUO
AbbexaBSGabx066474Mouse Basigin (BSG) ProteinMouseRecombinantE. coliUnconjugatedWB, SDS-PAGE22510 µgP18572RUO
AbbexaBSGabx620030Human Basigin (BSG) ProteinHumanRecombinantE. coliSDS-PAGE25050 µgP35613RUO

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