Human Basigin (BSG) Protein
260€ (50 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Basigin (BSG) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx620030
tested applications
SDS-PAGE
Description
Human Basigin (BSG) Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Basigin (BSG) |
| Host | E. coli |
| Origin | Human |
| Observed MW | Molecular Weight: Calculated MW: 22.6 kDa Sequence Fragment: Ala22-Ala207 Tag: His tag |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Size 3 | 1 mg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.5. |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| UniProt ID | P35613 |
| Gene ID | 682 |
| OMIM | 109480 |
| Alias | OK,5F7,TCSF,CD147,EMPRIN,HAb18G,EMMPRIN,Leukocyte activation antigen M6,Extracellular matrix metalloproteinase inducer,Ok blood group,Tumor cell-derived collagenase stimulatory factor |
| Background | Protein BSG |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Basigin (BSG), also known as CD147 or extracellular matrix metalloproteinase inducer (EMMPRIN), is a transmembrane glycoprotein widely expressed across tissues and involved in diverse physiological and pathological processes, including cell adhesion, metabolism, and immune responses. BSG is best known for its role in promoting tumor progression and metastasis by stimulating the production of matrix metalloproteinases (MMPs) in tumor and stromal cells, facilitating extracellular matrix remodeling and invasion. It also regulates cellular metabolism by interacting with monocarboxylate transporters (MCTs), mediating the transport of lactate and pyruvate, which are critical for glycolytic metabolism in rapidly proliferating cells. BSG is expressed at high levels in tumor tissues and is considered a biomarker for cancer aggressiveness and poor prognosis. In addition to its role in cancer, BSG participates in immune modulation, acting as a co-stimulatory molecule in T-cell activation and playing roles in viral infections, such as acting as a receptor for certain pathogens, including the malaria parasite Plasmodium falciparum. Structurally, BSG contains two Ig-like domains that mediate interactions with a wide array of ligands and partner proteins, enabling its multifunctional roles. Its upregulation in inflammatory and fibrotic diseases further underscores its significance in pathological conditions beyond cancer. Basigin's central role in cellular communication and its overexpression in disease states make it an attractive target for therapeutic interventions, with ongoing research exploring monoclonal antibodies and small molecule inhibitors to modulate its activity.
Related Products
Human CD147(Extracellular Matrix Metalloproteinase Inducer) ELISA Kit
Ver Producto
Rat Bsg(Basigin) ELISA Kit
Ver Producto
anti- CD147 antibody
The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene.
Ver Producto