anti- CD147 antibody
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935106861
info@markelab.com
name
anti- CD147 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01430
tested applications
ELISA, WB, IHC
Description
The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | basigin (Ok blood group) |
| Host | Rabbit |
| Reactivity | human,mouse |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 42 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P35613 |
| Gene ID | 682 |
| Alias | OK,5F7,TCSF,CD147,EMPRIN,HAb18G,EMMPRIN,Leukocyte activation antigen M6,Extracellular matrix metalloproteinase inducer,Ok blood group,Tumor cell-derived collagenase stimulatory factor |
| Background | Antibody anti-BSG |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
Basigin (BSG), also known as CD147 or extracellular matrix metalloproteinase inducer (EMMPRIN), is a transmembrane glycoprotein widely expressed across tissues and involved in diverse physiological and pathological processes, including cell adhesion, metabolism, and immune responses. BSG is best known for its role in promoting tumor progression and metastasis by stimulating the production of matrix metalloproteinases (MMPs) in tumor and stromal cells, facilitating extracellular matrix remodeling and invasion. It also regulates cellular metabolism by interacting with monocarboxylate transporters (MCTs), mediating the transport of lactate and pyruvate, which are critical for glycolytic metabolism in rapidly proliferating cells. BSG is expressed at high levels in tumor tissues and is considered a biomarker for cancer aggressiveness and poor prognosis. In addition to its role in cancer, BSG participates in immune modulation, acting as a co-stimulatory molecule in T-cell activation and playing roles in viral infections, such as acting as a receptor for certain pathogens, including the malaria parasite Plasmodium falciparum. Structurally, BSG contains two Ig-like domains that mediate interactions with a wide array of ligands and partner proteins, enabling its multifunctional roles. Its upregulation in inflammatory and fibrotic diseases further underscores its significance in pathological conditions beyond cancer. Basigin's central role in cellular communication and its overexpression in disease states make it an attractive target for therapeutic interventions, with ongoing research exploring monoclonal antibodies and small molecule inhibitors to modulate its activity.
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anti- CD147 antibody
The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene.
Ver Producto