APOE - Apolipoprotein E | Elisa - Clia - Antibody - Protein

Family main features

Backgroud:

Apolipoprotein E (APOE) is a protein encoded by the APOE gene located on chromosome 19 in humans. It plays a crucial role in lipid metabolism, particularly in the transport and metabolism of cholesterol and other lipids. APOE is primarily synthesized in the liver, brain, and various peripheral tissues. APOE is a polymorphic protein, meaning it can exist in different isoforms encoded by three common alleles: ε2, ε3, and ε4. These isoforms differ in their amino acid sequences, resulting in variations in protein structure and function. The primary function of APOE is to facilitate the uptake and clearance of lipoproteins, such as chylomicrons, very low-density lipoproteins (VLDL), and remnants of these lipoproteins, from the bloodstream. APOE acts as a ligand for cell surface receptors, including the low-density lipoprotein receptor (LDLR) and the LDL receptor-related protein (LRP), mediating the uptake of lipoprotein particles into cells. In addition to its role in lipid metabolism, APOE is involved in various physiological processes, including neuronal repair, synaptic plasticity, and inflammation modulation. In the central nervous system, APOE is synthesized by astrocytes and microglia and is critical for the maintenance and repair of neuronal membranes. It plays a role in the clearance of amyloid beta peptides, which are implicated in the pathogenesis of Alzheimer's disease.The expression of the APOE gene can be influenced by various factors, including dietary nutrients, hormones, and transcriptional regulators. Factors such as peroxisome proliferator-activated receptors (PPARs), liver X receptors (LXRs), and retinoid X receptors (RXRs) can modulate APOE expression levels.Genetic variations in the APOE gene, particularly the ε4 allele, have been associated with an increased risk of cardiovascular diseases, such as atherosclerosis and coronary artery disease, as well as neurodegenerative diseases, including Alzheimer's disease. Individuals carrying the ε4 allele may have higher levels of cholesterol and an increased risk of developing these diseases compared to those with the ε2 or ε3 alleles.


Protein Structure:

  • Primary Structure: APOE is a 299-amino acid protein.
  • Secondary Structure: The protein predominantly consists of alpha-helices.
  • Tertiary Structure: APOE has a globular structure with a distinct N-terminal domain responsible for receptor binding and a C-terminal domain involved in lipid binding.
  • Quaternary Structure: APOE functions as a monomer but can form dimers or multimers, particularly when lipid-bound.


Classification and Subtypes:

APOE belongs to the apolipoprotein family, which includes various proteins that bind lipids to form lipoproteins. APOE exists in three major isoforms, which differ by single amino acid substitutions:

  • APOE2 (Cys112, Cys158)
  • APOE3 (Cys112, Arg158)
  • APOE4 (Arg112, Arg158)

These isoforms have different biochemical properties and associations with disease risk.


Function and Biological Significance:

  • Lipid Transport: APOE plays a key role in the transport and clearance of triglyceride-rich lipoproteins and is crucial for the normal catabolism of triglyceride-rich lipoprotein constituents.
  • Receptor Binding: It mediates the binding of lipoproteins to the LDL receptor and other cell surface receptors, facilitating lipid uptake by cells.
  • Neuronal Repair and Maintenance: In the brain, APOE is involved in the redistribution of lipids during neuronal repair and remodeling.
  • Anti-atherogenic Role: By promoting cholesterol efflux and reducing inflammation, APOE has protective effects against atherosclerosis.


Interactions:

  • Lipoprotein Interactions: APOE is a component of several types of lipoproteins, including chylomicrons, VLDL, IDL, and HDL.
  • Receptor Interactions: APOE interacts with LDL receptors, LDL receptor-related protein (LRP), and other receptors involved in lipid metabolism.
  • Ligand Binding: APOE can bind to heparin, phospholipids, and cholesterol, which is essential for its role in lipid transport and metabolism.


Clinical Issues:

  • Alzheimer’s Disease: The APOE ε4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease, associated with earlier onset and increased disease severity.
  • Cardiovascular Disease: APOE polymorphisms influence plasma lipid levels, with APOE ε2 and ε4 associated with varying risks of hyperlipidemia and cardiovascular diseases.
  • Lipid Metabolism Disorders: Mutations and polymorphisms in APOE can lead to dyslipidemias, such as Type III hyperlipoproteinemia (familial dysbetalipoproteinemia).
  • Neurodegenerative Diseases: Beyond Alzheimer's disease, APOE is implicated in other neurodegenerative conditions due to its role in lipid transport and neuronal repair.


Summary:

Apolipoprotein E (APOE) is a vital protein in lipid metabolism and neuronal function, with significant roles in transporting and clearing lipids, binding to lipid receptors, and aiding in neuronal repair. APOE's three isoforms, resulting from genetic polymorphisms, exhibit distinct biochemical properties that influence disease risk, particularly for Alzheimer's disease and cardiovascular diseases. Understanding APOE's structure, function, and interactions offers critical insights into its role in health and disease, making it a key target for therapeutic intervention and genetic studies.



APOE Recommended name:

Apolipoprotein E(ApoE)

Aliases for APOE

APOE, AD2, APO-E, LDLCQ5, LPG, apolipoprotein E, ApoE4, Apo E

En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits, CLIA Kits) relacionados con APOE - Apolipoprotein E

Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.

Esta página contiene 74 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda

Contacta con nosotros en info@markelab.com, si necesitas mas informacion o alguna aclaracion. Te garantizamos respuesta en menos de 24 h.

immunoassays

providerCodereferencenamereactivitysample typeassay typetest rangesensitivitypricesize 1uniprot idstatus
AbbexaAPOEabx513773Cow Apolipoprotein E (APOE) ELISA KitCowSerum,Plasma,Other biological fluids0.156 ng/ml - 10 ng/ml687.596 testsQ03247RUO
AbbexaAPOEabx491912Dog Apolipoprotein E (APOE) CLIA KitDogSerum, plasma and other biological fluids.Sandwich1.56 ng/ml - 100 ng/ml< 0.65 ng/ml84596 testsRUO
AbbexaAPOEabx150225Dog Apolipoprotein E (APOE) ELISA KitDogSerum,Plasma,Other biological fluidsSandwich1.56 ng/ml - 100 ng/ml< 0.65 ng/ml687.596 testsRUO
FineTestAPOEEH0549Human APOE(Apolipoprotein E) ELISA KithumanSerum,Plasma,Tissue homogenates,Other biological fluidsSandwich ELISA, Double Antibody1.25-80ng/ml96TP02649RUO
AbbexaAPOEabx150717Human Apolipoprotein E (APOE) ELISA KitHumanSerum,Plasma,Other biological fluidsSandwich4.7 ng/ml - 300 ng/ml< 1.9 ng/ml512.596 testsRUO
AbbexaAPOEabx190132Human Apolipoprotein E (APOE) CLIA KitHumanSerum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.Sandwich0.82 ng/ml - 600 ng/ml< 0.37 ng/ml84596 testsRUO
AbbexaAPOEabx195168Human Apolipoprotein E (ApoE) CLIA KitHumanSerum, plasma and other biological fluids.Sandwich4.69 ng/ml - 300 ng/ml2.82 ng/ml643.596 testsRUO
FineTestAPOEEMK0009Monkey ApoE(Apolipoprotein E) ELISA KitmonkeyBusacar en las instruccionesSandwich ELISA, Double Antibody6.25-400ng/ml96TP10517RUO
AbbexaAPOEabx255341Monkey Apolipoprotein E (APOE) ELISA KitMonkeySerum,Plasma,Tissue homogenates,Cell lysates,Other biological fluidsSandwich6.25 ng/ml - 400 ng/ml3.75 ng/ml60096 testsRUO
FineTestAPOEEM0846Mouse APO-E(Apolipoprotein E) ELISA KitmouseSerum,Plasma,Tissue homogenates,Other biological fluidsSandwich ELISA, Double Antibody1.563-100ng/ml96TP08226RUO
AbbexaAPOEabx255191Mouse Apolipoprotein E (APOE) ELISA KitMouseSerum,Plasma,Other biological fluidsSandwich1.56 ng/ml - 100 ng/ml0.94 ng/ml52596 testsP08226RUO
AbbexaAPOEabx153664Mouse Apolipoprotein E (APOE) ELISA KitMouseSerum,Plasma,Other biological fluidsSandwich15.6 ng/ml - 1000 ng/ml< 6.7 ng/ml618.7596 testsRUO
AbbexaAPOEabx491913Mouse Apolipoprotein E (APOE) CLIA KitMouseSerum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.Sandwich15.6 ng/ml - 1000 ng/ml< 6.7 ng/ml84596 testsRUO
AbbexaAPOEabx196722Mouse Apolipoprotein E (APOE) CLIA KitMouseSerum, plasma and other biological fluids.Sandwich0.31 ng/ml - 20 ng/ml0.19 ng/ml643.596 testsRUO
AbbexaAPOEabx154889Pig Apolipoprotein E (APOE) ELISA KitPigSerum,Plasma,Other biological fluidsSandwich0.312 ng/ml - 20 ng/ml< 0.15 ng/ml712.596 testsRUO
AbbexaAPOEabx491914Pig Apolipoprotein E (APOE) CLIA KitPigSerum, plasma and other biological fluids.Sandwich0.312 ng/ml - 20 ng/ml< 0.144 ng/ml84596 testsRUO
FineTestAPOEEP0018Porcine ApoE(Apolipoprotein E) ELISA KitporcineBusacar en las instruccionesSandwich ELISA, Double Antibody1.25-80ng/ml96TP18650RUO
FineTestAPOEERB0014Rabbit ApoE(Apolipoprotein E) ELISA KitrabbitSerum,Plasma,Tissue homogenates,Other biological fluidsSandwich ELISA, Double Antibody3.125-200ng/ml96TP18287RUO
AbbexaAPOEabx155039Rabbit Apolipoprotein E (APOE) ELISA KitRabbitSerum,Plasma,Other biological fluidsCompetitive493.8 pg/ml - 40000 pg/ml< 182.5 pg/ml67596 testsRUO
AbbexaAPOEabx490213Rabbit Apolipoprotein E (APOE) CLIA KitRabbitSerum, plasma and other biological fluids.Competitive493.83 pg/ml - 40000 pg/ml< 182.5 pg/ml84596 testsRUO
AbbexaAPOEabx052466Rabbit Apolipoprotein E (APOE) ELISA KitRabbitSerum,Plasma,Other biological fluidsSandwich0.625 ng/ml - 40 ng/ml0.38 ng/ml618.7596 testsRUO
FineTestAPOEER0353Rat Apoe(Apolipoprotein E) ELISA KitratSerum,Plasma,Tissue homogenates,Other biological fluidsSandwich ELISA, Double Antibody3.125-200ng/ml96TP02650RUO
AbbexaAPOEabx256331Rat Apolipoprotein E (APOE) ELISA KitRatSerum,Plasma,Other biological fluidsSandwich1.25 ng/ml - 80 ng/ml0.75 ng/ml556.2596 testsRUO
AbbexaAPOEabx491915Rat Apolipoprotein E (APOE) CLIA KitRatSerum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.Sandwich6.25 ng/ml - 400 ng/ml< 2.55 ng/ml84596 testsRUO
AbbexaAPOEabx155222Rat Apolipoprotein E (APOE) ELISA KitRatSerum,Plasma,Other biological fluidsSandwich6.25 ng/ml - 400 ng/ml< 2.92 ng/ml67596 testsRUO
AbbexaAPOEabx195169Rat Apolipoprotein E (ApoE) CLIA KitRatSerum, plasma and other biological fluids.Sandwich0.625 ng/ml - 40 ng/ml0.38 ng/ml643.596 testsRUO
AbbexaAPOEabx052467Rat Apolipoprotein E (APOE) ELISA KitRatSerum,Plasma,Other biological fluidsSandwich3.125 ng/ml - 200 ng/ml1.88 ng/ml556.2596 testsP02650RUO

Primary Antibodies

providerCodereferencenamereactivityclonalityhostimmunogen targetisotypeconjugationtested applicationspricesize 1uniprot idstatus
AbbexaAPOEabx024092Apolipoprotein E (Apo E) VLDL AntibodyMonoclonalMouseApolipoprotein E (Apo E) VLDLELISA, WB, IHC-F10751 mlRUO
AbbexaAPOEabx023256Apolipoprotein E (Apo E) AntibodyPolyclonalGoatApolipoprotein E (Apo E)UnconjugatedELISA, WB13751 mgRUO
AbbexaAPOEabx104920Apolipoprotein E (APOE) AntibodyDogPolyclonalRabbitApolipoprotein E (APOE)UnconjugatedWB, IHC, IF/ICC275100 µlP18649RUO
AbbexaAPOEabx171284Apolipoprotein E (APOE) AntibodyDogMonoclonalMouseApolipoprotein E (APOE)UnconjugatedWB, IHC, IF/ICC812.51 mlRUO
FineTestAPOEFNab10127anti- APOE antibodyhumanpolyclonalRabbitapolipoprotein E 33BIgGUnconjugatedELISA, WB, IHC, IF100µgP02649RUO
AbbexaAPOEabx315383Apolipoprotein E (APOE) Antibody (Biotin)HumanPolyclonalRabbitApolipoprotein E (APOE)BiotinELISA162.520 µgP02649RUO
AbbexaAPOEabx010563Apolipoprotein E (ApoE) AntibodyHumanMonoclonalMouseApolipoprotein E (ApoE)UnconjugatedELISA, IHC, FCM362.5100 µlP02649RUO
AbbexaAPOEabx101447Apolipoprotein E (APOE) AntibodyHumanPolyclonalRabbitApolipoprotein E (APOE)UnconjugatedWB, IHC, IF/ICC237.5100 µlP02649RUO
AbbexaAPOEabx323324Apolipoprotein E (APOE) AntibodyHumanPolyclonalRabbitApolipoprotein E (APOE)UnconjugatedELISA, WB187.550 µgP02649RUO
AbbexaAPOEabx315382Apolipoprotein E (APOE) Antibody (FITC)HumanPolyclonalRabbitApolipoprotein E (APOE)FITC162.520 µgP02649RUO
AbbexaAPOEabx342004Apolipoprotein E4 (APOE4) AntibodyHumanMonoclonalMouseApolipoprotein E4UnconjugatedELISA, SDS-PAGE750100 µgP02649RUO
AbbexaAPOEabx432347Apolipoprotein E (APOE) AntibodyHumanPolyclonalGoatApolipoprotein E (APOE)UnconjugatedP-ELISA, WB387.5200 µlRUO
AbbexaAPOEabx415075Apolipoprotein E (Apo E) Antibody (Biotin)HumanMonoclonalMouseApolipoprotein E (Apo E)BiotinELISA, WB600100 µgP02649RUO
AbbexaAPOEabx015177Apolipoprotein E (APOE) AntibodyHumanPolyclonalRabbitApolipoprotein E (APOE)UnconjugatedELISA, WB43.7510 µgP02649RUO
AbbexaAPOEabx019017Apolipoprotein E (ApoE) AntibodyHumanPolyclonalRabbitApolipoprotein E (ApoE)UnconjugatedWB300100 µgP02649RUO
AbbexaAPOEabx170017Apolipoprotein E (APOE) AntibodyHumanPolyclonalRabbitApolipoprotein E (APOE)UnconjugatedWB, IHC, IF/ICC237.5100 µlP02649RUO
AbbexaAPOEabx171281Apolipoprotein E (APOE) AntibodyHumanMonoclonalMouseApolipoprotein E (APOE)UnconjugatedWB, IHC, IF/ICC637.51 mlRUO
AbbexaAPOEabx301032Apolipoprotein E (APOE) AntibodyHumanPolyclonalRabbitApolipoprotein E (APOE)UnconjugatedELISA, IHC, IF/ICC162.520 µgP02649RUO
AbbexaAPOEabx315381Apolipoprotein E (APOE) Antibody (HRP)HumanPolyclonalRabbitApolipoprotein E (APOE)HRPELISA162.520 µgP02649RUO
AbbexaAPOEabx370549Apolipoprotein E (APOE) Antibody PairHumanApolipoprotein E (APOE)ELISA10505 × 96 testsRUO
AbbexaAPOEabx033494Apolipoprotein E (APOE) AntibodyHumanPolyclonalRabbitApolipoprotein E (APOE)UnconjugatedELISA, WB, IHC281.2580 µlP02649RUO
AbbexaAPOEabx328373Apolipoprotein E (APOE) AntibodyHumanPolyclonalRabbitApolipoprotein E (APOE)UnconjugatedELISA, WB, IHC187.550 µgP02649RUO
AbbexaAPOEabx147973Apolipoprotein E (APOE) AntibodyHumanPolyclonalRabbitApolipoprotein E (APOE)UnconjugatedELISA, WB, IHC, IF/ICC350100 µgP02649RUO
AbbexaAPOEabx007195Apolipoprotein E (ApoE) AntibodyHumanPolyclonalRabbitApolipoprotein E (ApoE)UnconjugatedWB, IHC, IF/ICC17520 µlP02649RUO
AbbexaAPOEabx271337Apolipoprotein E (APOE) Antibody (Biotin)MousePolyclonalRabbitApolipoprotein E (APOE)BiotinWB, IHC, IF/ICC337.5200 µlRUO
AbbexaAPOEabx107992Apolipoprotein E (APOE) Antibody (HRP)MousePolyclonalRabbitApolipoprotein E (APOE)HRPELISA162.520 µgP08226RUO
AbbexaAPOEabx175439Apolipoprotein E (APOE) AntibodyMousePolyclonalRabbitApolipoprotein E (APOE)UnconjugatedWB, IHC, IF/ICC262.5100 µlRUO
AbbexaAPOEabx106575Apolipoprotein E (APOE) Antibody (FITC)MousePolyclonalRabbitApolipoprotein E (APOE)FITC162.520 µgP08226RUO
AbbexaAPOEabx370424Apolipoprotein E (APOE) Antibody PairMouseApolipoprotein E (APOE)ELISA13505 × 96 testsRUO
AbbexaAPOEabx101448Apolipoprotein E (APOE) AntibodyMousePolyclonalRabbitApolipoprotein E (APOE)UnconjugatedWB, IHC, IF/ICC262.5100 µlP08226RUO
AbbexaAPOEabx109551Apolipoprotein E (APOE) AntibodyMousePolyclonalRabbitApolipoprotein E (APOE)UnconjugatedELISA, WB162.520 µgP08226RUO
AbbexaAPOEabx105158Apolipoprotein E (APOE) Antibody (Biotin)MousePolyclonalRabbitApolipoprotein E (APOE)BiotinELISA162.520 µgP08226RUO
AbbexaAPOEabx271074Apolipoprotein E (APOE) Antibody (FITC)MousePolyclonalRabbitApolipoprotein E (APOE)FITCWB, IHC, IF/ICC412.5200 µlRUO
AbbexaAPOEabx132168Apolipoprotein E (APOE) AntibodyPigPolyclonalRabbitApolipoprotein E (APOE)UnconjugatedWB, IHC, IF/ICC287.5100 µlP18650RUO
AbbexaAPOEabx171285Apolipoprotein E (APOE) AntibodyPigMonoclonalMouseApolipoprotein E (APOE)UnconjugatedWB, IHC, IF/ICC8501 mlRUO
AbbexaAPOEabx370376Apolipoprotein E (APOE) Antibody PairRatApolipoprotein E (APOE)ELISA1437.55 × 96 testsRUO
AbbexaAPOEabx171282Apolipoprotein E (APOE) AntibodyRatMonoclonalMouseApolipoprotein E (APOE)UnconjugatedWB, IHC, IF/ICC275100 µlP02650RUO
AbbexaAPOEabx101449Apolipoprotein E (APOE) AntibodyRatPolyclonalRabbitApolipoprotein E (APOE)UnconjugatedWB, IHC, IF/ICC262.5100 µlP02650RUO

Proteins and Peptides

providerCodereferencenameoriginexpressionhostconjugationtested applicationspricesize 1uniprot idstatus
AbbexaAPOEabx652555Pig Apolipoprotein E (APOE) ProteinPigRecombinantE. coliUnconjugatedWB, SDS-PAGE2112.51 mgRUO
AbbexaAPOEabx694213Human Apolipoprotein E (APOE) ProteinHumanRecombinantHEK293 cellsSDS-PAGE40020 µgP02649RUO
AbbexaAPOEabx065429Human Apolipoprotein E (APOE) ProteinHumanRecombinantE. coliUnconjugatedWB, SDS-PAGE187.510 µgP02649RUO
FineTestAPOEP4435Recombinant Human Apolipoprotein EHumanRecombinantE.ColiWestern Blot,ELISA50μgP02649RUO
FineTestAPOEP4586Recombinant Mouse Apolipoprotein EMouseRecombinantE.ColiWestern Blot,ELISA50μgP08226RUO
AbbexaAPOEabx065427Rat Apolipoprotein E (APOE) ProteinRatRecombinantE. coliUnconjugatedWB, SDS-PAGE237.510 µgP02650RUO
AbbexaAPOEabx652556Rabbit Apolipoprotein E (APOE) ProteinRabbitRecombinantE. coliUnconjugatedWB, SDS-PAGE2112.51 mgRUO
AbbexaAPOEabx168028Dog Apolipoprotein E (APOE) ProteinDogRecombinantE. coliUnconjugatedWB, SDS-PAGE45050 µgRUO
AbbexaAPOEabx065426Mouse Apolipoprotein E (APOE) ProteinMouseRecombinantE. coliUnconjugatedWB, SDS-PAGE22510 µgP08226RUO

Te recomendamos que si no encuentras lo que buscas, utilices el buscador, refinando la búsqueda según tu criterio y usando Alias, o bien contacta con nosotros.